F9
Reactivity: Human
WB, ELISA
Host: Rabbit
Polyclonal
unconjugated
Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Concentration
3.5 mg/mL
Buffer
0.05 M Sodium Phosphate, 0.5 M NaCl, 1 mM EDTA, pH 6.6
Handling Advice
Avoid repeated freezing and thawing.
Storage
-80 °C
Storage Comment
Store at -70 °C.
Target
Coagulation Factor IX (F9)
Background
Coagulation Factor IX (F9) circulates in the blood as an inactive zymogen. This factor is converted to an active form by factor XIa, which excises the activation peptide and thus generates a heavy chain and a light chain held together by one or more disulfide bonds. The role of this activated factor IX in the blood coagulation cascade is to activate factor X to its active form through interactions with Ca+2 ions, membrane phospholipids, and factor VIII. Alterations of this gene, including point mutations, insertions and deletions, cause factor IX deficiency, which is a recessive X-linked disorder, also called hemophilia B or Christmas disease.Synonyms: Christmas factor, PTC, Plasma thromboplastin component