Complement Factor B antibody (Middle Region)

Catalog No. ABIN951644

The Rabbit Polyclonal anti-Complement Factor B antibody is suitable to detect Complement Factor B in samples from Human and Mouse. It has been validated for WB, IHC (p) and EIA.

Quick Overview for Complement Factor B antibody (Middle Region) (ABIN951644)

Target: Complement Factor B (CFB)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Complement Factor B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-Complement Factor B Antibody

Binding Specificity: AA 474-504, Middle Region

Specificity: This antibody reacts to CFB.

Cross-Reactivity (Details): Species reactivity (tested):Human and Mouse.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 474~504 amino acids from the Center region of human CFB

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Complement Factor B

Target: Complement Factor B (CFB)

Alternative Name: Complement Factor B

Background: CFB encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation.Synonyms: BF, BFD, C3/C5 convertase, CFB, Glycine-rich beta glycoprotein, PBF2, Properdin factor B

Molecular Weight: 85533 Da

Gene ID: 629

NCBI Accession: NP_001701

Pathways: Complement System, Proton Transport, Ribonucleoside Biosynthetic Process