CTPS2 antibody (C-Term)

Catalog No. ABIN951729

This anti-CTPS2 antibody is a Rabbit Polyclonal antibody detecting CTPS2 in WB and EIA. Suitable for Human.

Quick Overview for CTPS2 antibody (C-Term) (ABIN951729)

Target: CTPS2 (CTP Synthase II (CTPS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTPS2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-CTPS2 Antibody

Binding Specificity: AA 449-479, C-Term

Specificity: This antibody reacts to CTPS2.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 449-479 amino acids from the C-terminal region of human CTPS2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CTPS2

Target: CTPS2 (CTP Synthase II (CTPS2))

Alternative Name: CTP Synthase 2

Background: The protein encoded by this gene catalyzes the formation of CTP from UTP with the concomitant deamination of glutamine to glutamate. This protein is the rate-limiting enzyme in the synthesis of cytosine nucleotides, which play an important role in various metabolic processes and provide the precursors necessary for the synthesis of RNA and DNA. Cancer cells that exhibit increased cell proliferation also exhibit an increased activity of this encoded protein. Thus, this protein is an attractive target for selective chemotherapy. Three alternatively spliced transcript variants encoding the same protein have been described for this gene.Synonyms: CTP synthetase 2, CTPS2, UTP-ammonia ligase 2

Molecular Weight: 65678 Da

Gene ID: 56474

NCBI Accession: NP_001137474

Pathways: Ribonucleoside Biosynthetic Process