FBXO4 antibody (Middle Region)

Catalog No. ABIN952288

This Rabbit Polyclonal antibody specifically detects FBXO4 in WB and EIA. It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for FBXO4 antibody (Middle Region) (ABIN952288)

Target: FBXO4 (F-Box Protein 4 (FBXO4))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FBXO4 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-FBXO4 Antibody

Binding Specificity: AA 231-260, Middle Region

Specificity: This antibody recognizes Human FBXO4 (Center).

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 231~260 amino acids from the Center region of human FBXO4

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-FBXO4 antibody (ABIN952288)

Barbash, Zamfirova, Lin, Chen, Yang, Nakagawa, Lu, Rustgi, Diehl: "Mutations in Fbx4 inhibit dimerization of the SCF(Fbx4) ligase and contribute to cyclin D1 overexpression in human cancer." in: Cancer cell, Vol. 14, Issue 1, pp. 68-78, (2008) (PubMed).

Target Details for FBXO4

Target: FBXO4 (F-Box Protein 4 (FBXO4))

Alternative Name: FBXO4

Background: FBXO4 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein belongs to the Fbxs class.Synonyms: F-box only protein 4, FBX4

Molecular Weight: 44136 Da

Gene ID: 26272

NCBI Accession: NP_036308