GLIS2 antibody (Middle Region)

Catalog No. ABIN952526

The Rabbit Polyclonal anti-GLIS2 antibody has been validated for WB and EIA. It is suitable to detect GLIS2 in samples from Human.

Quick Overview for GLIS2 antibody (Middle Region) (ABIN952526)

Target: GLIS2 (GLIS Family Zinc Finger 2 (GLIS2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GLIS2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-GLIS2 Antibody

Binding Specificity: AA 172-202, Middle Region

Specificity: This antibody recognizes Human GLIS2 (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 172-202 amino acids from the Central region of Human GLIS2.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GLIS2

Target: GLIS2 (GLIS Family Zinc Finger 2 (GLIS2))

Alternative Name: GLIS2

Background: This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.Synonyms: GLI-similar 2, NKL, Neuronal Krueppel-like protein, Zinc finger protein GLIS2

Molecular Weight: 55689 Da

Gene ID: 84662

NCBI Accession: NP_115964