MHC Class I H-2KdDd antibody (Biotin)

Catalog No. ABIN371168

The Mouse Monoclonal anti-MHC Class I H-2KdDd antibody is suitable to detect MHC Class I H-2KdDd in samples from Mouse. It has been validated for FACS.

Quick Overview for MHC Class I H-2KdDd antibody (Biotin) (ABIN371168)

Target: MHC Class I H-2KdDd

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: Biotin

Application: Flow Cytometry (FACS)

Clone: 34-1-2S

Product Details

Purification: Protein G Chromatography

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details

Target: MHC Class I H-2KdDd

Alternative Name: MHC Class I H2 Kd/Dd

Background: The 'classical' MHC Class I molecules are histocompatibility antigens encoded by the H-2 gene complex and consist of heterodimers of highly polymorphic alpha chains noncovalently associated with the invariant beta 2-Microglobulin. (Ref.3,4) These antigens are expressed on most nucleated cells but expression varies on different cell types. MHC Class I molecules present endogenously synthesized peptides to CD8+ T lymphocytes, which are usually cytotoxic T cells. (Ref.5) MHC Class I antigens expressed on thymic epithelial cells regulate the positive and negative selection of CD8+ T cells during T cell ontogeny. (Ref.3,6)