COBRA1 antibody (Middle Region)

Catalog No. ABIN953646

This anti-COBRA1 antibody is a Rabbit Polyclonal antibody detecting COBRA1 in WB and EIA. Suitable for Human.

Quick Overview for COBRA1 antibody (Middle Region) (ABIN953646)

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COBRA1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-COBRA1 Antibody

Binding Specificity: AA 255-285, Middle Region

Specificity: This antibody reacts to COBRA1.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 255-285 amino acids from the Central region of human COBRA1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for COBRA1

Target: COBRA1 (Cofactor of BRCA1 (COBRA1))

Alternative Name: NELF-B

Background: NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2, MIM 606026), either NELFC or NELFD (TH1L, MIM 605297), and NELFE (RDBP, MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1, MIM 603555) and SPT5 (SUPT5H, MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).Synonyms: COBRA1, Cofactor of BRCA1, KIAA1182, NELFB, Negative elongation factor B

Molecular Weight: 65697 Da

Gene ID: 25920

NCBI Accession: NP_056271