RBM5 antibody (N-Term)

Catalog No. ABIN954485

The Rabbit Polyclonal anti-RBM5 antibody has been validated for WB and EIA. It is suitable to detect RBM5 in samples from Human.

Quick Overview for RBM5 antibody (N-Term) (ABIN954485)

Target: RBM5 (RNA Binding Motif Protein 5 (RBM5))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RBM5 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-RBM5 Antibody

Binding Specificity: AA 17-46, N-Term

Specificity: This antibody recognizes Human RBM5 (N-term).

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 17-46 amino acids from the N-terminal region of Human RBM5. Genename: RBM5

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for RBM5

Target: RBM5 (RNA Binding Motif Protein 5 (RBM5))

Alternative Name: RBM5 / LUCA15

Background: Component of the spliceosome A complex. Regulates alternative splicing of a number of mRNAs. May modulate splice site pairing after recruitment of the U1 and U2 snRNPs to the 5' and 3' splice sites of the intron. May both positively and negatively regulate aopotosis by regulating the alternative splicing of several genes involved in this process, including FAS and CASP2/caspase-2. In the case of FAS, promotes exclusion of exon 6 thereby producing a soluble form of FAS that inhibits apoptosis. In the case of CASP2/caspase-2, promotes exclusion of exon 9 thereby producing a catalytically active form of CASP2/Caspase-2 that induces apoptosisSynonyms: NY-REN-9, Putative tumor suppressor LUCA15, RNA-binding motif protein 5, RNA-binding protein 5, Renal carcinoma antigen NY-REN-9

Molecular Weight: 92154 Da

Gene ID: 10181

NCBI Accession: NP_005769

Pathways: Ribonucleoprotein Complex Subunit Organization