SPG20 antibody (C-Term)

Catalog No. ABIN954907

This Rabbit Polyclonal antibody specifically detects SPG20 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for SPG20 antibody (C-Term) (ABIN954907)

Target: SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPG20 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-SPG20 Antibody

Binding Specificity: AA 490-519, C-Term

Specificity: This antibody recognizes Human

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 490-519 amino acids from the C-terminal region of Human SPG20 Genename: SPG20

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Target Details for SPG20

Target: SPG20 (Spastic Paraplegia 20 (Troyer Syndrome) (SPG20))

Alternative Name: Spartin / SPG20

Background: SPG20 is a protein containing a MIT (Microtubule Interacting and Trafficking molecule) domain, and is implicated in regulating endosomal trafficking and mitochondria function. The protein localizes to mitochondria and partially co-localizes with microtubules. Stimulation with epidermal growth factor (EGF) results in protein translocation to the plasma membrane, and the protein functions in the degradation and intracellular trafficking of EGF receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified. Mutations associated with this gene cause autosomal recessive spastic paraplegia 20 (Troyer syndrome)Synonyms: KIAA0610, Spastic paraplegia 20 protein, TAHCCP1, Trans-activated by hepatitis C virus core protein 1

Molecular Weight: 72833 Da

Gene ID: 23111

NCBI Accession: NP_001135766

Pathways: Regulation of Cell Size, SARS-CoV-2 Protein Interactome