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STIM1 antibody (C-Term)

This anti-STIM1 antibody is a Rabbit Polyclonal antibody detecting STIM1 in WB, IHC (p) and EIA. Suitable for Human.
Catalog No. ABIN954978

Quick Overview for STIM1 antibody (C-Term) (ABIN954978)

Target

See all STIM1 Antibodies
STIM1 (Stromal Interaction Molecule 1 (STIM1))

Reactivity

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  • 1
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Human

Host

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Rabbit

Clonality

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Polyclonal

Conjugate

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This STIM1 antibody is un-conjugated

Application

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
  • Binding Specificity

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    AA 516-546, C-Term

    Specificity

    This antibody reacts to STIM1.

    Cross-Reactivity (Details)

    Species reactivity (tested):Human.

    Purification

    Affinity chromatography on Protein A

    Immunogen

    KLH conjugated synthetic peptide between 516-546 amino acids from the C-terminal region of human STIM1

    Isotype

    Ig Fraction
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    0.25 mg/mL

    Buffer

    PBS, 0.09 % (W/V) sodium azide

    Preservative

    Sodium azide

    Precaution of Use

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handling Advice

    Avoid repeated freezing and thawing.

    Storage

    4 °C/-20 °C

    Storage Comment

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target

    STIM1 (Stromal Interaction Molecule 1 (STIM1))

    Alternative Name

    STIM1 / GOK

    Background

    This gene encodes a type 1 transmembrane protein that mediates Ca2+ influx after depletion of intracellular Ca2+ stores by gating of store-operated Ca2+ influx channels (SOCs). It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region, as well as early hematopoiesis, by mediating attachment to stromal cells. This gene is oriented in a head-to-tail configuration with the ribonucleotide reductase 1 gene (RRM1), with the 3' end of this gene situated 1.6 kb from the 5' end of the RRM1 gene.Synonyms: Stromal interaction molecule 1

    Molecular Weight

    77423 Da

    Gene ID

    6786

    NCBI Accession

    NP_003147

    Pathways

    TCR Signaling, BCR Signaling
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