STK38 antibody (AA 365-466)

Catalog No. ABIN954986

The Mouse Monoclonal anti-STK38 antibody has been validated for WB, IHC (p) and EIA. It is suitable to detect STK38 in samples from Human, Mouse and Rat.

Quick Overview for STK38 antibody (AA 365-466) (ABIN954986)

Target: STK38 (serine/threonine Kinase 38 (STK38))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This STK38 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: 6F1

Product Details anti-STK38 Antibody

Binding Specificity: AA 365-466

Specificity: Recognizes STK38

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Protein A Chromatography

Immunogen: STK38 (AAH12085, 365 a.a. ~ 466 a.a) partial recombinant protein with GST tag.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for STK38

Target: STK38 (serine/threonine Kinase 38 (STK38))

Alternative Name: STK38

Background: STK38 contains 1 protein kinase domain that interacts with mob1 and mob2.The homodimeric s100b binds to two molecules of stk38. It is ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Stk38 activated by binding of s100b which releases autoinhibitory n-lobe interactions, enabling atp to bind and the autophosphorylation of ser-281. thr-444 then undergoes calcium- dependent phosphorylation by an upstream kinase. Interactions between phosphorylated thr-444 and the n-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of mob1/mobkl1a and mob2/hcca2 to the n-terminal of stk38.Synonyms: NDR1, Nuclear Dbf2-related kinase 1, Serine/threonine-protein kinase 38

Gene ID: 11329

NCBI Accession: NP_009202

UniProt: Q15208