T-Box 1 antibody (C-Term)

Catalog No. ABIN955110

This anti-T-Box 1 antibody is a Rabbit Polyclonal antibody detecting T-Box 1 in WB, IHC (p) and EIA. Suitable for Human.

Quick Overview for T-Box 1 antibody (C-Term) (ABIN955110)

Target: T-Box 1 (TBX1)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This T-Box 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-T-Box 1 Antibody

Binding Specificity: AA 334-364, C-Term

Specificity: This antibody reacts to TBX1.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 334~364 amino acids from the C-terminal region of human TBX1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for T-Box 1

Target: T-Box 1 (TBX1)

Alternative Name: TBX1

Background: TBX1 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product shares 98 % amino acid sequence identity with the mouse ortholog. DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS), a common congenital disorder characterized by neural-crest-related developmental defects, has been associated with deletions of chromosome 22q11.2, where this gene has been mapped. Studies using mouse models of DiGeorge syndrome suggest a major role for this gene in the molecular etiology of DGS/VCFS. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene.Synonyms: T-box protein 1, T-box transcription factor TBX1, Testis-specific T-box protein

Molecular Weight: 43133 Da

Gene ID: 6899

NCBI Accession: NP_005983

Pathways: Retinoic Acid Receptor Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation