Uromodulin antibody

Catalog No. ABIN955477

This Mouse Monoclonal antibody specifically detects Uromodulin in IHC (p), IF, IHC (fro) and EIA. It exhibits reactivity toward Human and Dog.

Quick Overview for Uromodulin antibody (ABIN955477)

Target: Uromodulin (UMOD)

Reactivity: Human, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This Uromodulin antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: 01-10-32

Product Details anti-Uromodulin Antibody

Specificity: Anti-Human Tamm-Horsfall protein (THP) is a monoclonal antibody which reacts with an epitope of the urinary mucoprotein. This monoclonal antibody has shown good localization to the distal tubule and collecting duct as well as to large deposits of Tamm-Horsfall protein which has clogged peri-pelvic veins.

Cross-Reactivity (Details): Species reactivity (expected):Canine (Dog).
Species reactivity (tested):Human.

Purification: Protein G Chromatography.

Immunogen: Human Tamm-Horsfall protein.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Uromodulin

Target: Uromodulin (UMOD)

Background: Tamm-Horsfall Protein (THP) is a glycoprotein of approximately 80 kDa containing up to 25 % carbohydrate by weight. It exists as a high molecular weight polymer in urine and approximately 50 mg of the THP are excreted per day by adult humans. THP is produced by the epithelial cells lining the thick ascending loop of Henle and distal convoluted tubules of the kidney. THP is also the primary constituent of renal tubular casts and THP aggregation has been implicated as a factor in the pathogenesis of acute renal failure by causing tubular obstruction. Antibody to THP is present in the serum of patients with pyelonephritis and reflus uropathy.Synonyms: THP, Tamm-Horsfall urinary glycoprotein

Gene ID: 7369

NCBI Accession: NP_001008390

UniProt: P07911