Wiskott-Aldrich Syndrome (Eczema-thrombocytopenia) (WAS) (AA 122-152), (Middle Region) antibody Primary Antibody
WAS Reactivity: Human, Mouse EIA, FACS, IHC (p), WB Host: Rabbit Polyclonal
Catalog No. ABIN955540
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- Binding Specificity
- AA 122-152, Middle Region
- Human, Mouse
- Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
- This antibody detectas WAS / IMD2 (Center).
- Cross-Reactivity (Details)
- Species reactivity (tested):Human, mouse
- Protein A column followed by peptide affinity purification
- KLH conjugated synthetic peptide between 122~152 amino acids from the Central region of human WAS
- Ig Fraction
- Application Notes
- Optimal working dilution should be determined by the investigator.
- For Research Use only
- 0.25 mg/mL
- PBS with 0.09 % (W/V) sodium azide
- Sodium azide
- Precaution of Use
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Avoid repeated freezing and thawing.
- 4 °C/-20 °C
- Storage Comment
- Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
- Alternative Name
- WAS / IMD2 (WAS Antibody Abstract)
- The Wiskott-Aldrich syndrome (WAS) family of proteins share similar domain structure, and are involved in transduction of signals from receptors on the cell surface to the actin cytoskeleton. The presence of a number of different motifs suggests that they are regulated by a number of different stimuli, and interact with multiple proteins. Recent studies have demonstrated that these proteins, directly or indirectly, associate with the small GTPase, Cdc42, known to regulate formation of actin filaments, and the cytoskeletal organizing complex, Arp2/3. Wiskott-Aldrich syndrome is a rare, inherited, X-linked, recessive disease characterized by immune dysregulation and microthrombocytopenia, and is caused by mutations in the WAS gene. The WAS gene product is a cytoplasmic protein, expressed exclusively in hematopoietic cells, which show signalling and cytoskeletal abnormalities in WAS patients.Synonyms: WASp, Wiskott-Aldrich syndrome protein
- Gene ID
- NCBI Accession
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