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ATP6V0A4 antibody (C-Term)

ATP6V0A4 Reactivity: Human IHC Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN965622
  • Target See all ATP6V0A4 Antibodies
    ATP6V0A4 (ATPase, H+ Transporting, Lysosomal V0 Subunit A4 (ATP6V0A4))
    Binding Specificity
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reactivity
    • 12
    • 2
    Human
    Host
    • 11
    • 1
    Rabbit
    Clonality
    • 11
    • 1
    Polyclonal
    Conjugate
    • 11
    • 1
    This ATP6V0A4 antibody is un-conjugated
    Application
    • 9
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC)
    Purification
    Purified by antigen-specific affinity chromatography.
    Immunogen
    Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of Human ATP6V0A4(ATPase, H+ transporting, lysosomal V0 subunit aisoform 4)
    Top Product
    Discover our top product ATP6V0A4 Primary Antibody
  • Application Notes
    ELISA, Western blotting: 1µg/ml for 2hrs.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    This antibody is stored in PBS, 50% glycerol
    Preservative
    Sodium azide
    Precaution of Use
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
  • Target
    ATP6V0A4 (ATPase, H+ Transporting, Lysosomal V0 Subunit A4 (ATP6V0A4))
    Alternative Name
    ATP6V0A4 (ATP6V0A4 Products)
    Background
    ATP6V0A4(ATPase, H+ transporting, lysosomal V0 subunit aisoform 4) is a component of vacuolar ATPase(V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. V-ATPase is comprised of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of a hexamer of three A and three B subunits plus the C, D, and E subunits. It contains the ATP catalytic site. The ATP6V0A4 protein is one of three 116 kD subunits family. This family consists of the 116kDa V-type ATPase (vacuolar H+)-ATPases) subunits, as well as V-type ATP synthase subunit i. The V-type ATPases family are proton pumps that acidify intracellular compartments in eukaryotic cells for example yeast central vacuoles, clathrin-coated and synaptic vesicles. They have important roles in membrane trafficking processes. The 116kDa subunit (subunit a) in the V-type ATPase is part of the V0 functional domain responsible for proton transport. The a subunit is a transmembrane glycoprotein with multiple putative transmembrane helices it has a hydrophilic amino terminal and a hydrophobic carboxy terminal. It has roles in proton transport and assembly of the V-type ATPase complex. This subunit is encoded by two homologous gene in yeast VPH1 and STV1
    Pathways
    Sensory Perception of Sound, Transition Metal Ion Homeostasis, Proton Transport
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