Integrin beta 3 antibody

Catalog No. ABIN965812

This Mouse Monoclonal antibody specifically detects Integrin beta 3 in FACS, IHC (fro) and IHC (p). It exhibits reactivity toward Humanand has been mentioned in 1 publication.

Quick Overview for Integrin beta 3 antibody (ABIN965812)

Target: Integrin beta 3 (ITGB3)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Integrin beta 3 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: Y2-51

Product Details anti-Integrin beta 3 Antibody

Purification: Concentrated.

Immunogen: Phytohemagglutinin-stimulated Human Mononuclear Cells

Isotype: IgG1

Application Details

Application Notes: Immunohistochemistry: (Paraffin/Frozen (acetone fixed)) 1:50-1:100, FLOW.
Staining Procedure: Prolonged fixation in buffered formalin can destroy the epitope. The antibody may be used at a dilution of 1:50 -1:100 in IHC. When using paraffin-embedded and formalin-fixed tissues, enzymatic predigestion is required. The optimal conditions should be determined by the individual laboratory.

Comment:

Cellular Localization: Cell Membrane.
Recommended Positive Control: Lymphoid Tissues

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/ml.

Buffer: 20 mM Tris-Borate, 150 mM Sodium Chloride, dialyzed media RPMI 1640/D-MEM containing Fetal Bovine Serum, BMC-6 Carrier Polysaccharides, Carrier Protein, pH 7.5

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-Integrin beta 3 antibody (ABIN965812)

Ford-Hutchinson: "Regulation of leukotriene biosynthesis." in: Cancer metastasis reviews, Vol. 13, Issue 3-4, pp. 257-67, (1995) (PubMed).

Target Details for Integrin beta 3

Target: Integrin beta 3 (ITGB3)

Alternative Name: CD61, Platelet Glycoprotein IIIa

Background: This antibody reacts with platelet glycoprotein IIIa, a 110 kD glycoprotein present on human platelets and megakaryocytic progenitors. This antibody reacts with platelets, megakaryocytes, megakaryoblasts, endothelium, and osteoclasts.

Gene ID: 3690

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, Smooth Muscle Cell Migration, Integrin Complex