GJB1 antibody (AA 215-231)

Catalog No. ABIN965915

Product Details anti-GJB1 Antibody

Target: GJB1 (Gap Junction Protein, beta 1, 32kDa (GJB1))

Binding Specificity: AA 215-231

Reactivity: Human, Rat

Host: Please inquire

Clonality: Polyclonal

Conjugate: This GJB1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Immunogen: A synthetic peptide corresponding to a sequence at the middle region of human Connexin 32 (215-231aa), identical to the related mouse and rat sequence.

Application Details

Restrictions: For Research Use only

Handling

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Preservative: Thimerosal (Merthiolate), Sodium azide

Storage: -20 °C

References for anti-GJB1 antibody (ABIN965915)

Hoek, Schlegel, Eichhoff, Widmer, Praetorius, Einarsson, Valgeirsdottir, Bergsteinsdottir, Schepsky, Dummer, Steingrimsson: "Novel MITF targets identified using a two-step DNA microarray strategy." in: Pigment cell & melanoma research, Vol. 21, Issue 6, pp. 665-76, (2008) (PubMed).

Corcos, Lafrenière, Begy, Loch-Caruso, Willard, Glover: "Refined localization of human connexin32 gene locus, GJB1, to Xq13.1." in: Genomics, Vol. 13, Issue 2, pp. 479-80, (1992) (PubMed).

Target Details for GJB1

Target: GJB1 (Gap Junction Protein, beta 1, 32kDa (GJB1))

Alternative Name: Connexin 32 (GJB1 Products)

Background: Connexins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and small molecules between cells (Bergoffen et al., 1993). For a general discussion of connexin proteins, also known as Gap junction beta-1 protein. Gap junction beta-1 protein is a protein that in humans is encoded by the GJB1 gene.In melanocytic cells GJB1 gene expression may be regulated by MITF.

Pathways: Cell-Cell Junction Organization