Dynamin 1 antibody

Catalog No. ABIN966017

The Monoclonal anti-Dynamin 1 antibody has been validated for WB, ELISA and IHC. It is suitable to detect Dynamin 1 in samples from Human. There is 1 publication available.

Quick Overview for Dynamin 1 antibody (ABIN966017)

Target: Dynamin 1 (DNM1)

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This Dynamin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-Dynamin 1 Antibody

Specificity: Ni-NTA purified truncated recombinant Dynamin-1 expressed in E. Coli strain BL21 (DE3)

Purification: Crude ascites.

Isotype: IgG2a

Application Details

Application Notes: Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
IHC(F): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000 Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: -20 °C

References for anti-Dynamin 1 antibody (ABIN966017)

Yoo, Jeong, Kwon, Hur, Park, Han: "Activation of dynamin I gene expression by Sp1 and Sp3 is required for neuronal differentiation of N1E-115 cells." in: The Journal of biological chemistry, Vol. 277, Issue 14, pp. 11904-9, (2002) (PubMed).

Target Details for Dynamin 1

Target: Dynamin 1 (DNM1)

Alternative Name: Dynamin-1

Background: Dynamin-1 (Dyn1), with 864-amino acid protein (about 95kDa), belongs to the dynamin family. Dynamin-1 (neuron-specific), dynamin-2 (ubiquitously expressed), and dynamin-3 (expressed only in the testis, brain, and lung), constitute the dynamin family. Members of the dynamin family are GPTase, microtubule-associated proteins which are involved in endocytosis, synaptic transmission and neurogenesis. Dynamin-1 is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C. Dynamin-1 is a large GTPase enzyme required in membrane constriction and fission during multiple forms of endocytosis. Dynamin-1 is also a key molecule required for the recycling of synaptic vesicles in neurons, and it has been known that dynamin-1 gene expression is induced during neuronal differentiation.

Pathways: Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling