Estrogen Receptor alpha antibody (Estrogen Receptor 1)

Details for Product anti-ESR1 Antibody No. ABIN966105
Target
Reactivity
Human
594
255
206
40
33
12
10
9
7
7
5
5
4
3
3
1
1
Host
Rabbit
453
177
2
1
1
Clonality
Polyclonal
Conjugate
This Estrogen Receptor alpha antibody is un-conjugated
42
24
24
17
16
13
12
12
12
12
12
11
6
6
6
6
6
4
4
4
4
4
4
4
4
4
4
4
4
4
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC)
446
212
207
143
103
80
79
55
55
18
16
16
13
13
11
9
7
3
2
1
1
1
1
1
1
1
1
1
1
1
Options
Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human Estrogen Receptor- around the phosphorylation site of serine167 (L-A-SP-T-N).
Specificity Estrogen Receptor- (Ab-167) antibody detects endogenous levels of total Estrogen Receptor- protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Target
Alternative Name Estrogen Receptor-alpha (ESR1 Antibody Abstract)
Pathways Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
Application Notes WB: 1:500~1:1000
IHC: 1:50~1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Shah, Rowan: "The Src kinase pathway promotes tamoxifen agonist action in Ishikawa endometrial cells through phosphorylation-dependent stabilization of estrogen receptor (alpha) promoter interaction and elevated steroid receptor coactivator 1 activity." in: Molecular endocrinology (Baltimore, Md.), Vol. 19, Issue 3, pp. 732-48, 2005 (PubMed).

Campbell, Bhat-Nakshatri, Patel, Constantinidou, Ali, Nakshatri: "Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: a new model for anti-estrogen resistance." in: The Journal of biological chemistry, Vol. 276, Issue 13, pp. 9817-24, 2001 (PubMed).