FER Tyrosine Kinase (FER) antibody

Details for Product No. ABIN966133
Target
Reactivity
Human, Mouse
105
91
54
10
6
6
3
2
1
1
Host
Mouse
107
11
1
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
8
6
6
4
4
4
4
4
4
4
4
4
2
2
2
2
2
1
Application
Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
84
50
28
26
15
13
8
6
4
2
2
2
1
Options
Immunogen Purified recombinant fragment of human FER expressed in E. Coli.
Clone 5D2C4
Isotype IgG1
Purification Ascitic fluid
Target
Alternative Name FER (FER Antibody Abstract)
Background FER (fer tyrosine kinase) is a member of the FPS/FES family of nontransmembrane receptor tyrosine kinases, which shares a functional domain and is involved in signaling pathways through receptor tyrosine kinases (RTK) and cytokine receptors. The Fes /Fps family is distinct from c-Src, c-Abl and related nRTKs and was originally distinguished as a homolog to retroviral oncoproteins. In vivo, Fer kinase assembles into homotrimers via conserved coiled-coil domains. The N-terminal coiled-coil domains of Fer can autophosphorylate in trans, thereby regulating their cellular function through differential phosphorylation states. Growth factor exposure can induce tyrosine phosphorylation of Fer and recruitment of Fer to RTK complexes containing p85. It is expressed predominantly in mature hematopoietic cells of the granulocytic and monocytic lineage, and has been shown to be expressed in vascular endothelial cells. Fer is implicated in insulin signaling, cell-cell signaling, human prostatic proliferative diseases, and is involved in the regulation of G1 progression.
Synonyms: TYK3, FER
Molecular Weight 95kDa
Gene ID 2241
Application Notes Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Format Liquid
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Product cited in: Li, Cheng, Ling: "Isolation and characterization of Fe(III)-chelate reductase gene LeFRO1 in tomato." in: Plant molecular biology, Vol. 54, Issue 1, pp. 125-36, 2004 (PubMed).

Girault, Greengard: "The neurobiology of dopamine signaling." in: Archives of neurology, Vol. 61, Issue 5, pp. 641-4, 2004 (PubMed).

Fan, Di Ciano-Oliveira, Weed, Craig, Greer, Rotstein, Kapus: "Actin depolymerization-induced tyrosine phosphorylation of cortactin: the role of Fer kinase." in: The Biochemical journal, Vol. 380, Issue Pt 2, pp. 581-91, 2004 (PubMed).