GSTP1 antibody

Catalog No. ABIN966240

This anti-GSTP1 antibody is a Monoclonal antibody detecting GSTP1 in WB, IHC and ELISA. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for GSTP1 antibody (ABIN966240)

Target: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Reactivity: Human

Host: Please inquire

Clonality: Monoclonal

Conjugate: This GSTP1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Product Details anti-GSTP1 Antibody

Specificity: Ni-NTA purified truncated recombinant GSTP1 expressed in E. Coli strain BL21 (DE3)

Purification: Antibodies are purified by protein A affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
IHC(F): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test.

Restrictions: For Research Use only

Handling

Storage: -20 °C

References for anti-GSTP1 antibody (ABIN966240)

Lin, Nelson: "Methyl-CpG-binding domain protein-2 mediates transcriptional repression associated with hypermethylated GSTP1 CpG islands in MCF-7 breast cancer cells." in: Cancer research, Vol. 63, Issue 2, pp. 498-504, (2003) (PubMed).

Satoh, Itoh, Yamamoto, Tanaka, Hayakari, Ookawa, Yamazaki, Sato, Tsuchida, Hatayama: "Nrf2 transactivator-independent GSTP1-1 expression in "GSTP1-1 positive" single cells inducible in female mouse liver by DEN: a preneoplastic character of possible initiated cells." in: Carcinogenesis, Vol. 23, Issue 3, pp. 457-62, (2002) (PubMed).

Target Details for GSTP1

Target: GSTP1 (Glutathione S-Transferase pi 1 (GSTP1))

Alternative Name: GSTP1

Background: GSTP1 (glutathione-S-transferase, pi 1), also called GST3/DFN7, which is located on chromosome 11q13 , is a family of enzymes that play an important role in detoxification by catalyzing the conjugation of many hydrophobic and electrophilic compounds with reduced glutathione. GSTP1 act like a tumor suppressor gene, which when inactivated leads to tumor growth, and the -class glutathione S-transferase is commonly inactivated by somatic CpGisland hypermethylation in cancers of the prostate, liver, and breast. Methylation of regulatory sequences at the GSTP1 gene locus is found in the vast majority (>90%) of prostate carcinomas and is associated with transcriptional down-regulation.

Gene ID: 2950

Pathways: Cellular Response to Molecule of Bacterial Origin