LCav2b (Isoform B) antibody

Catalog No. ABIN966478

This Rabbit Polyclonal antibody specifically detects LCav2b in IHC. It exhibits reactivity toward Great Pond Snail (Lymnaea stagnalis). It has been mentioned in 3+ publications

Quick Overview for LCav2b (Isoform B) antibody (ABIN966478)

Target: LCav2b

Reactivity: Great Pond Snail (Lymnaea stagnalis)

Host: Rabbit

Clonality: Polyclonal

Application: Immunohistochemistry (IHC)

Product Details

Binding Specificity: Isoform B

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to near N-terminal residues of Great Pond Snail (Lymnaea stagnalis) LCav2b (voltage-dependent non-L-type calcium channel alpha-1 subunit isoform b)

Application Details

Restrictions: For Research Use only

Handling

Storage: 4 °C

References

Spafford, Van Minnen, Larsen, Smit, Syed, Zamponi: "Uncoupling of calcium channel alpha1 and beta subunits in developing neurons." in: The Journal of biological chemistry, Vol. 279, Issue 39, pp. 41157-67, (2004) (PubMed).

Spafford, Munno, Van Nierop, Feng, Jarvis, Gallin, Smit, Zamponi, Syed: "Calcium channel structural determinants of synaptic transmission between identified invertebrate neurons." in: The Journal of biological chemistry, Vol. 278, Issue 6, pp. 4258-67, (2003) (PubMed).

Spafford, Chen, Feng, Smit, Zamponi: "Expression and modulation of an invertebrate presynaptic calcium channel alpha1 subunit homolog." in: The Journal of biological chemistry, Vol. 278, Issue 23, pp. 21178-87, (2003) (PubMed).

Target Details

Target: LCav2b

Background: LCav2b (voltage-dependent non-L-type calcium channel alpha-1 subunit isoform b) mediates entry of calcium ions into excitable cells. Calcium channel beta subunits are key modulators of calcium channel function and membrane targeting of the pore-forming alpha1 subunit. An invertebrate (Lymnaea stagnalis) homolog of P/Q- and N-type calcium channels (LCav2), although colocalized with beta subunits in synapses of mature neurons, is physically uncoupled from the beta subunits in the leading edge of growth cones of outgrowing neurons. LCav2 channels that mediate transmitter release in mature synapses also participate in neuronal outgrowth in growth cones. The differential association of beta subunits with synaptic calcium channels and those expressed in emergent neuronal growth shows that beta subunits may play a role in the transformation of Cav2 calcium channel function in immature neurons and mature synapses.