VEGFR2 antibody (Kinase insert Domain Receptor (A Type III Receptor tyrosine Kinase))

Details for Product anti-KDR Antibody No. ABIN967247
Antigen
Reactivity
Human, Mouse (Murine), Rat (Rattus)
599
356
212
26
7
5
5
4
4
2
2
2
2
2
2
2
2
2
2
1
1
1
1
Host
Rabbit
562
116
21
2
2
1
1
1
Clonality
Polyclonal
Conjugate
This VEGFR2 antibody is un-conjugated
44
26
25
22
14
12
10
10
10
10
10
10
3
3
3
3
3
3
3
2
2
2
2
1
1
Application
Immunohistochemistry (IHC)
458
265
245
142
118
103
31
29
26
22
22
19
16
8
8
4
2
1
Options
Immunogen The antiserum was produced against synthesized non-phosphopeptide derived from human VEGFR2 around the phosphorylation site of tyrosine 1175 (K-D-YP-I-V).
Specificity VEGFR2 (Ab-1175) antibody detects endogenous levels of total VEGFR2 protein.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Antigen
Alternative Name VEGFR2 (KDR Antibody Abstract)
Pathways RTK Signaling, Glycosaminoglycan Metabolic Process, Signaling Events mediated by VEGFR1 and VEGFR2, Growth Factor Binding, Regulation of long-term Neuronal Synaptic Plasticity, VEGF Signaling
Application Notes IHC: 1:50-1:100.
Restrictions For Research Use only
Format Liquid
Concentration 100ug/100ul.
Buffer Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Product cited in: Lamalice, Houle, Jourdan, Huot: "Phosphorylation of tyrosine 1214 on VEGFR2 is required for VEGF-induced activation of Cdc42 upstream of SAPK2/p38." in: Oncogene, Vol. 23, Issue 2, pp. 434-45, 2004 (PubMed).

Takahashi, Yamaguchi, Chida, Shibuya: "A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells." in: The EMBO journal, Vol. 20, Issue 11, pp. 2768-78, 2001 (PubMed).