MVP antibody (AA 403-592)

Catalog No. ABIN968013

This anti-MVP antibody is a Mouse Monoclonal antibody detecting MVP in WB, IHC, IF and IP. Suitable for Human, Cow, Rabbit and Dog. This Primary Antibody has been cited in 5+ publications.

Quick Overview for MVP antibody (AA 403-592) (ABIN968013)

Target: MVP (Major Vault Protein (MVP))

Reactivity: Human, Cow, Rabbit, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This MVP antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Clone: 42-LRP

Product Details anti-MVP Antibody

Binding Specificity: AA 403-592

Cross-Reactivity: Cow (Bovine), Dog (Canine), Rabbit

Characteristics: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human LRP aa. 403-592

Isotype: IgG1

Application Details

Comment:

Related Products: ABIN967389, ABIN968536

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store undiluted at -20°C.

References for anti-MVP antibody (ABIN968013)

Papura: "Managed care policy regarding OMT reimbursement illogical." in: The Journal of the American Osteopathic Association, Vol. 102, Issue 2, pp. 66, (2002) (PubMed).

Rybarova, Batekova, Hodorova, Mirossay, Kluchova, Bobrov, Kocisova: "Immunohistochemical detection of LRP protein in the normal human lung." in: Bratislavské lekárske listy, Vol. 102, Issue 2, pp. 66-72, (2001) (PubMed).

List, Spier, Grogan, Johnson, Roe, Greer, Wolff, Broxterman, Scheffer, Scheper, Dalton: "Overexpression of the major vault transporter protein lung-resistance protein predicts treatment outcome in acute myeloid leukemia." in: Blood, Vol. 87, Issue 6, pp. 2464-9, (1996) (PubMed).

Kickhoefer, Rome: "The sequence of a cDNA encoding the major vault protein from Rattus norvegicus." in: Gene, Vol. 151, Issue 1-2, pp. 257-60, (1995) (PubMed).

Scheffer, Wijngaard, Flens, Izquierdo, Slovak, Pinedo, Meijer, Clevers, Scheper: "The drug resistance-related protein LRP is the human major vault protein." in: Nature medicine, Vol. 1, Issue 6, pp. 578-82, (1995) (PubMed).

Target Details for MVP

Target: MVP (Major Vault Protein (MVP))

Alternative Name: LRP

Background: Drugs that selectively attack dividing cells are often used in cancer therapy. However, small cell populations do not die, but develop resistance to a variety of toxic drugs. Multidrug resistance is achieved by gene amplification of specific membrane-bound transport ATPases that shuttle the drugs out of cells. Some multidrug-resistant cancer cells express a protein of 110 kDa named LRP (Lung Resistance-related Protein). LRP expression might be an indicator of prognosis after chemotherapy in acute myeloid leukemia and ovarian carcinoma. The LRP gene encodes a protein of 896 amino acids with significant homology to the major vault protein from Dictyostelium discoideum. Although ubiquitously expressed, LRP is most abundant in epithelial cells.

Molecular Weight: 110 kDa