AAT antibody

Catalog No. ABIN968939

The Mouse Monoclonal anti- antibody has been validated for WB and ELISA. It is suitable to detect in samples from Human and Mouse. There are 2+ publications available.

Quick Overview for AAT antibody (ABIN968939)

Target: AAT

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 2B12

Product Details

Purpose: AAT Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human AAT expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References

El-Akawi, Al-Hindawi, Bashir: "Alpha-1 antitrypsin (alpha1-AT) plasma levels in lung, prostate and breast cancer patients." in: Neuro endocrinology letters, Vol. 29, Issue 4, pp. 482-4, (2008) (PubMed).

Liu, Qian, Gritsenko, Camp, Monroe, Moore, Smith: "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." in: Journal of proteome research, Vol. 4, Issue 6, pp. 2070-80, (2005) (PubMed).

Target Details

Target: AAT

Background: AAT, also known as SERPINA1, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1. It is secreted and is a serine protease inhibitor whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Severe Serpin A1 deficiency leads to several clinical complications such as pulmonary emphysema, juvenile hepatisis, cirrhosis and hepatocellular carcinoma.

Molecular Weight: 47 kDa

Gene ID: 5265

UniProt: P01009