ABL2 antibody

Catalog No. ABIN968944

This Mouse Monoclonal antibody specifically detects ABL2 in ELISA and ICC. It exhibits reactivity toward Human and Mouse and has been mentioned in 2+ publications.

Quick Overview for ABL2 antibody (ABIN968944)

Target: ABL2

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This ABL2 antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC)

Clone: 1H1

Product Details anti-ABL2 Antibody

Purpose: ABL2 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of ABL2 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-ABL2 antibody (ABIN968944)

Scheijen, Griffin: "Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease." in: Oncogene, Vol. 21, Issue 21, pp. 3314-33, (2002) (PubMed).

Iijima, Ito, Oikawa, Eguchi, Eguchi-Ishimae, Kamada, Kishi, Asano, Sakaki, Sato: "A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation." in: Blood, Vol. 95, Issue 6, pp. 2126-31, (2000) (PubMed).

Target Details for ABL2

Target: ABL2

Alternative Name: ABL2

Background: ABL2 (ARG, Abl-related gene), together with c-Abl, forms the Abl family of mammalian non-receptor tyrosine kinases. ABL2 and c-Abl share 89 % , 90 and 93 % identity in their SH3, SH2 and tyrosine domain, but only 29 % identity in the carboxy-terminal half. The human c-Abl and ABL2 genes are expressed ubiquitously. ABL2 had been detected predominantly in the cytoplasm, whereas c-Abl shows both cytoplasmic and nuclear localization. c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl. Recently, TEL-ARG fusion transcripts have also been identified in acute myeloid leukemias (AML). The Abl family kinases may also interact with receptor tyrosine signaling pathways and regulate cellular function such as cell cycle progression, gene transcription and organization of the actin cytoskeletons in neurons.

Molecular Weight: 128 kDa

Gene ID: 27

UniProt: P42684