c-Rel antibody

Catalog No. ABIN968997

This anti-c-Rel antibody is a Mouse Monoclonal antibody detecting c-Rel in WB, ELISA, IHC and ICC. Suitable for Human and Mouse. This Primary Antibody has been cited in 2+ publications.

Quick Overview for c-Rel antibody (ABIN968997)

Target: c-Rel (REL proto-oncogene (c-Rel))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This c-Rel antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Clone: 1E7

Product Details anti-c-Rel Antibody

Purpose: c-Rel Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human c-Rel expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-c-Rel antibody (ABIN968997)

Trynka, Zhernakova, Romanos, Franke, Hunt, Turner, Bruinenberg, Heap, Platteel, Ryan, de Kovel, Holmes, Howdle, Walters, Sanders, Mulder, Mearin, Verbeek, Trimble, Stevens, Kelleher, Barisani et al.: "Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. ..." in: Gut, Vol. 58, Issue 8, pp. 1078-83, (2009) (PubMed).

Garbati, Gilmore: "Ser484 and Ser494 in REL are the major sites of IKK phosphorylation in vitro: evidence that IKK does not directly enhance GAL4-REL transactivation." in: Gene expression, Vol. 14, Issue 4, pp. 195-205, (2008) (PubMed).

Target Details for c-Rel

Target: c-Rel (REL proto-oncogene (c-Rel))

Alternative Name: c-Rel

Background: The REL gene encodes c-Rel, a transcription factor that is a member of the Rel/NFKB family, which also includes RELA (MIM 164014), RELB (604758), NFKB1 (MIM 164011), and NFKB2 (MIM 164012). These proteins are related through a highly conserved N-terminal region termed the 'Rel domain,' which is responsible for DNA binding, dimerization, nuclear localization, and binding to the NFKB inhibitor.

Molecular Weight: 68.5 kDa

Gene ID: 5966

UniProt: Q04864