CD38 antibody

Catalog No. ABIN969023

The Mouse Monoclonal anti-CD38 antibody has been validated for IHC and ELISA. It is suitable to detect CD38 in samples from Human. There are 2+ publications available.

Quick Overview for CD38 antibody (ABIN969023)

Target: CD38

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD38 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA

Clone: 6E12D4A12

Product Details anti-CD38 Antibody

Purpose: CD38 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human CD38 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CD38 antibody (ABIN969023)

Pavón, Muñoz, Navarro, Raya-Alvarez, Callejas-Rubio, Navarro-Pelayo, Ortego-Centeno, Sancho, Zubiaur: "Increased association of CD38 with lipid rafts in T cells from patients with systemic lupus erythematosus and in activated normal T cells." in: Molecular immunology, Vol. 43, Issue 7, pp. 1029-39, (2005) (PubMed).

Liu, Verfaillie: "Myeloid-lymphoid initiating cells (ML-IC) are highly enriched in the rhodamine-c-kit(+)CD33(-)CD38(-) fraction of umbilical cord CD34(+) cells." in: Experimental hematology, Vol. 30, Issue 6, pp. 582-9, (2002) (PubMed).

Target Details for CD38

Target: CD38

Background: CD38 is a type II integral membrane glycoprotein which is present on early B and T cell lineages and activated B and T cells but is absent from most mature resting peripheral lymphocytes. CD38 is also found on thymocytes, pre-B cells, germinal center B cells, mitogen-activated T cells, monocytes and Ig-secreting plasma cells. CD38 acts as a NAD glycohydrolase in T lym- phocytes. On hematopoietic cells CD38 induces activation, proliferation, and differentiation of mature T and B cells and mediates apoptosis of myeloid and lymphoid progenitor cells. In addition to acting as a signaling receptor, CD38 is also an enzyme capable of producing several calcium-mobilizing metabo- lites, including cyclic adenosine diphosphate ribose (cADPR). CD38 also plays a role in maintaining survival of an invariant NK T (iNKT) cell subset that preferentially contributes to the maintenance of immunological tolerance.

Molecular Weight: 34 kDa

Gene ID: 952

UniProt: P28907