CRTC3 antibody

Catalog No. ABIN969068

Product Details anti-CRTC3 Antibody

Target: CRTC3 (CREB Regulated Transcription Coactivator 3 (CRTC3))

Reactivity: Human, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This CRTC3 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)

Purpose: CRTC3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human CRTC3 expressed in E. Coli.

Clone: 5G9

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CRTC3 antibody (ABIN969068)

Nakayama, Miyabe, Okabe, Sakuma, Ijichi, Hasegawa, Nagatsuka, Shimozato, Inagaki: "Clinicopathological significance of the CRTC3-MAML2 fusion transcript in mucoepidermoid carcinoma." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 22, Issue 12, pp. 1575-81, (2009) (PubMed).

Fehr, Röser, Heidorn, Hallas, Löning, Bullerdiek: "A new type of MAML2 fusion in mucoepidermoid carcinoma." in: Genes, chromosomes & cancer, Vol. 47, Issue 3, pp. 203-6, (2008) (PubMed).

Target Details for CRTC3

Target: CRTC3 (CREB Regulated Transcription Coactivator 3 (CRTC3))

Alternative Name: CRTC3 (CRTC3 Products)

Background: Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR) .Tissue specificity: Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.

Molecular Weight: 68 kDa

Gene ID: 64784

UniProt: Q6UUV7

Pathways: SARS-CoV-2 Protein Interactome, The Global Phosphorylation Landscape of SARS-CoV-2 Infection