CST3 antibody

Catalog No. ABIN969070

This Mouse Monoclonal antibody specifically detects CST3 in WB and ELISA. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for CST3 antibody (ABIN969070)

Target: CST3 (Cystatin C (CST3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CST3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 5H2

Product Details anti-CST3 Antibody

Purpose: CST3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human CST3 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-CST3 antibody (ABIN969070)

Helisalmi, Väkevä, Hiltunen, Soininen: "Flanking markers of cystatin c (CST3) gene do not show association with Alzheimer's disease." in: Dementia and geriatric cognitive disorders, Vol. 27, Issue 4, pp. 318-21, (2009) (PubMed).

Rehman, Fought, Solomon: "N-acetylcysteine effect on serum creatinine and cystatin C levels in CKD patients." in: Clinical journal of the American Society of Nephrology : CJASN, Vol. 3, Issue 6, pp. 1610-4, (2008) (PubMed).

Target Details for CST3

Target: CST3 (Cystatin C (CST3))

Alternative Name: CST3

Background: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and the kininogens. The type 2 cystatin proteins are a class of cysteine proteinase inhibitors found in a variety of human fluids and secretions, where they appear to provide protective functions. The cystatin locus on chromosome 20 contains the majority of the type 2 cystatin genes and pseudogenes. This gene is located in the cystatin locus and encodes the most abundant extracellular inhibitor of cysteine proteases, which is found in high concentrations in biological fluids and is expressed in virtually all organs of the body. A mutation in this gene has been associated with amyloid angiopathy. Expression of this protein in vascular wall smooth muscle cells is severely reduced in both atherosclerotic and aneurysmal aortic lesions, establishing its role in vascular disease. (provided by RefSeq)Tissue specificity: Expressed in submandibular and sublingual saliva but not in parotid saliva (at protein level). Expressed in various body fluids, such as the cerebrospinal fluid and plasma. Expressed in highest levels in the epididymis, vas deferens, brain, thymus, and ovary and the lowest in the submandibular gland.

Molecular Weight: 42 kDa

Gene ID: 1471

UniProt: P01034