Cytokeratin 5 antibody

Catalog No. ABIN969079

This Mouse Monoclonal antibody specifically detects Cytokeratin 5 in WB and ELISA. It exhibits reactivity toward Human and has been mentioned in 3+ publications.

Quick Overview for Cytokeratin 5 antibody (ABIN969079)

Target: Cytokeratin 5 (KRT5) (Keratin 5 (KRT5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cytokeratin 5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 1E1

Product Details anti-Cytokeratin 5 Antibody

Purpose: Cytokeratin 5 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of Cytokeratin 5 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Cytokeratin 5 antibody (ABIN969079)

Wang, Li: "Adenovirus-mediated RNA interference against collagen-specific molecular chaperone 47-KDa heat shock protein suppresses scar formation on mouse wounds." in: Cell biology international, Vol. 32, Issue 5, pp. 484-93, (2008) (PubMed).

Nishizawa, Izawa, Inoko, Hayashi, Nagata, Yokoyama, Usukura, Inagaki: "Identification of trichoplein, a novel keratin filament-binding protein." in: Journal of cell science, Vol. 118, Issue Pt 5, pp. 1081-90, (2005) (PubMed).

Gu, Kim, Ichiki, Park, Nagai, Kitajima: "A usual frameshift and delayed termination codon mutation in keratin 5 causes a novel type of epidermolysis bullosa simplex with migratory circinate erythema." in: The Journal of investigative dermatology, Vol. 121, Issue 3, pp. 482-5, (2003) (PubMed).

Target Details for Cytokeratin 5

Target: Cytokeratin 5 (KRT5) (Keratin 5 (KRT5))

Alternative Name: Cytokeratin 5

Background: Cytokeratin 5, also known as CK5, KRT5. It is a member of the keratin gene family. Biochemically, most members of the CK family fall into one of two classes, type I (acidic polypeptides) and type II (basic polypeptides). The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. At least one member of the acidic family and one member of the basic family is expressed in all epithelial cells. Cytokeratin 5 is expressed in normal basal cells. Mutations of the Cytokeratin5 gene (KRT5) have been shown to result in the autosomal dominant disorderepidermolysis bullosa (EB). Defects in KRT5 are a cause of epidermolysis bullosa simplex.

Molecular Weight: 62.3 kDa

Gene ID: 3852

UniProt: P13647