FGG antibody

Catalog No. ABIN969142

This Mouse Monoclonal antibody specifically detects FGG in IHC, ICC, ELISA and FACS. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for FGG antibody (ABIN969142)

Target: FGG (Fibrinogen gamma Chain (FGG))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FGG antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunocytochemistry (ICC), ELISA, Flow Cytometry (FACS)

Clone: 4H9

Product Details anti-FGG Antibody

Purpose: FGG Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human FGG expressed in E. Coli.

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-FGG antibody (ABIN969142)

Uitte de Willige, Standeven, Philippou, Ariëns: "The pleiotropic role of the fibrinogen gamma' chain in hemostasis." in: Blood, Vol. 114, Issue 19, pp. 3994-4001, (2009) (PubMed).

Bowley, Okumura, Lord: "Impaired protofibril formation in fibrinogen gamma N308K is due to altered D:D and "A:a" interactions." in: Biochemistry, Vol. 48, Issue 36, pp. 8656-63, (2009) (PubMed).

Target Details for FGG

Target: FGG (Fibrinogen gamma Chain (FGG))

Alternative Name: FGG

Background: The protein encoded by this gene is the gamma component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including dysfibrinogenemia, hypofibrinogenemia and thrombophilia. Alternative splicing results in two transcript variants encoding different isoforms.

Molecular Weight: 52 kDa

Gene ID: 2266

UniProt: P02679