FGG antibody (AA 278-437)

Catalog No. ABIN7152763

Product Details anti-FGG Antibody

Target: FGG (Fibrinogen gamma Chain (FGG))

Binding Specificity: AA 278-437

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGG antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Cross-Reactivity: Human, Mouse

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Fibrinogen gamma chain protein (278-437AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:200-1:5000, IHC:1:20-1:200, IF:1:50-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for FGG

Target: FGG (Fibrinogen gamma Chain (FGG))

Alternative Name: FGG (FGG Products)

Synonyms: FXII antibody, HAF antibody, 3010002H13Rik antibody, AI256424 antibody, fibrinogen antibody, FGG antibody, LOC100220680 antibody, fb60h05 antibody, fb62e01 antibody, wu:fb60h05 antibody, wu:fb62e01 antibody, zgc:56023 antibody, fibrinogen gamma chain antibody, coagulation factor XII (Hageman factor) antibody, fibrinogen gamma chain L homeolog antibody, FGG antibody, F12 antibody, fgg antibody, Fgg antibody, fgg.L antibody, CpipJ_CPIJ006387 antibody, CpipJ_CPIJ010087 antibody

Background:

Background: Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.

Aliases: FGG antibody, FIBG_HUMAN antibody, Fibrinogen gamma chain antibody, Fibrinogen gamma polypeptide antibody, fibrinogen gamma-b chain antibody

UniProt: P02679