FLT1 antibody

Catalog No. ABIN969146

The Mouse Monoclonal anti-FLT1 antibody has been validated for ELISA. It is suitable to detect FLT1 in samples from Human. There are 2+ publications available.

Quick Overview for FLT1 antibody (ABIN969146)

Target: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FLT1 antibody is un-conjugated

Application: ELISA

Clone: 3D10

Product Details anti-FLT1 Antibody

Purpose: FLT1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant extracellular fragment of human FLT1 fused with hIgGFc tag expressed in HEK293 cells.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-FLT1 antibody (ABIN969146)

Man, Yang, Cai, Yao, Zheng: "Immunolocalization and expression of vascular endothelial growth factor receptors (VEGFRs) and neuropilins (NRPs) on keratinocytes in human epidermis." in: Molecular medicine (Cambridge, Mass.), Vol. 12, Issue 7-8, pp. 127-36, (2006) (PubMed).

Flick, Sapi, Perrotta, Maher, Halaban, Carter, Kacinski: "Recognition of activated CSF-1 receptor in breast carcinomas by a tyrosine 723 phosphospecific antibody." in: Oncogene, Vol. 14, Issue 21, pp. 2553-61, (1997) (PubMed).

Target Details for FLT1

Target: FLT1 (Fms-Related tyrosine Kinase 1 (VEGFR1) (FLT1))

Alternative Name: FLT1

Background: Fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor), also known as FLT1 or VEGFR-1. It is a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.

Molecular Weight: 100 kDa

Gene ID: 2321

UniProt: P17948

Pathways: RTK Signaling, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals