Glucose-6-Phosphate Dehydrogenase antibody

Catalog No. ABIN969161

The Mouse Monoclonal anti-Glucose-6-Phosphate Dehydrogenase antibody has been validated for WB, IHC, ELISA and FACS. It is suitable to detect Glucose-6-Phosphate Dehydrogenase in samples from Human. There are 2+ publications available.

Quick Overview for Glucose-6-Phosphate Dehydrogenase antibody (ABIN969161)

Target: Glucose-6-Phosphate Dehydrogenase (G6PD)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Glucose-6-Phosphate Dehydrogenase antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 5E12

Product Details anti-Glucose-6-Phosphate Dehydrogenase Antibody

Purpose: G6PD Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human G6PD expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Glucose-6-Phosphate Dehydrogenase antibody (ABIN969161)

Louicharoen, Patin, Paul, Nuchprayoon, Witoonpanich, Peerapittayamongkol, Casademont, Sura, Laird, Singhasivanon, Quintana-Murci, Sakuntabhai: "Positively selected G6PD-Mahidol mutation reduces Plasmodium vivax density in Southeast Asians." in: Science (New York, N.Y.), Vol. 326, Issue 5959, pp. 1546-9, (2009) (PubMed).

Brajovich, Rucci, Acosta, Cotorruelo, García Borrás, Racca, Biondi, Racca: "Effects of aging on antioxidant response and phagocytosis in senescent erythrocytes." in: Immunological investigations, Vol. 38, Issue 6, pp. 551-9, (2009) (PubMed).

Target Details for Glucose-6-Phosphate Dehydrogenase

Target: Glucose-6-Phosphate Dehydrogenase (G6PD)

Alternative Name: G6PD

Background: This gene encodes glucose-6-phosphate dehydrogenase. This protein is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. G6PD is remarkable for its genetic diversity. Many variants of G6PD, mostly produced from missense mutations, have been described with wide ranging levels of enzyme activity and associated clinical symptoms. G6PD deficiency may cause neonatal jaundice, acute hemolysis, or severe chronic non-spherocytic hemolytic anemia. Two transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 59 kDa

Gene ID: 2539

UniProt: P11413

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones