Glutamate Receptor 3 antibody

Catalog No. ABIN969177

Product Details anti-Glutamate Receptor 3 Antibody

Target: Glutamate Receptor 3 (GRIA3) (Glutamate Receptor, Ionotropic, AMPA 3 (GRIA3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Glutamate Receptor 3 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Purpose: GRIA3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human GRIA3 expressed in E. Coli.

Clone: 1D2

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Glutamate Receptor 3 antibody (ABIN969177)

Utge, Soronen, Partonen, Loukola, Kronholm, Pirkola, Nyman, Porkka-Heiskanen, Paunio: "A population-based association study of candidate genes for depression and sleep disturbance." in: American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics, Vol. 153B, Issue 2, pp. 468-76, (2010) (PubMed).

Bonnet, Leheup, Béri, Philippe, Grégoire, Jonveaux: "Aberrant GRIA3 transcripts with multi-exon duplications in a family with X-linked mental retardation." in: American journal of medical genetics. Part A, Vol. 149A, Issue 6, pp. 1280-9, (2009) (PubMed).

Target Details for Glutamate Receptor 3

Target: Glutamate Receptor 3 (GRIA3) (Glutamate Receptor, Ionotropic, AMPA 3 (GRIA3))

Alternative Name: GRIA3 (GRIA3 Products)

Background: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes composed of multiple subunits, arranged to form ligand-gated ion channels. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The subunit encoded by this gene belongs to a family of AMPA (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate)-sensitive glutamate receptors, and is subject to RNA editing (AGA->GGA, R->G). Alternative splicing at this locus results in different isoforms, which may vary in their signal transduction properties.

Molecular Weight: 101 kDa

Gene ID: 2892

UniProt: P42263

Pathways: PI3K-Akt Signaling, cAMP Metabolic Process, Synaptic Membrane