ICAM1 antibody (AA 28-480)

Catalog No. ABIN969206

The Mouse Monoclonal anti-ICAM1 antibody has been validated for ELISA. It is suitable to detect ICAM1 in samples from Human. There is 1 publication available.

Quick Overview for ICAM1 antibody (AA 28-480) (ABIN969206)

Target: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ICAM1 antibody is un-conjugated

Application: ELISA

Clone: 6G12

Product Details anti-ICAM1 Antibody

Binding Specificity: AA 28-480

Purpose: ICAM1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human ICAM1(28-480aa) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-ICAM1 antibody (ABIN969206)

Yang, Cullen, Li, Chapman, Jewell: "Susceptibility to primary sclerosing cholangitis is associated with polymorphisms of intercellular adhesion molecule-1." in: Journal of hepatology, Vol. 40, Issue 3, pp. 375-9, (2004) (PubMed).

Target Details for ICAM1

Target: ICAM1 (Intercellular Adhesion Molecule 1 (ICAM1))

Alternative Name: ICAM1

Background: ICAM1 is a 85-110 kDa single chain type 1 integral membrane glycoprotein with an extracellular domain of five immunoglobulin superfamily repeats, a transmembrane region and a cytoplasmic domain. It shares considerable amino acid sequence homology with ICAM3 and with ICAM2. ICAM1 is expressed by activated endothelial cells. It is detected on cells of many other lineages (e.g. epithelial cells, fibroblasts, chondrocytes, B lymphocytes, T lymphocytes (low), monocytes, macrophages, dendritic cells and neutrophils), with lower levels that increase in inflammation. ICAM1 is also detected in some carcinoma and melanoma cells. Soluble ICAM1 is detectable in the plasma and is elevated in patients with various inflammatory syndromes. It is the receptor for rhinoviruses and malaria.

Molecular Weight: 57.8 kDa

Gene ID: 3383

UniProt: P05362

Pathways: Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Carbohydrate Homeostasis, Regulation of Leukocyte Mediated Immunity, Thromboxane A2 Receptor Signaling