MSI2 antibody

Catalog No. ABIN969295

This Mouse Monoclonal antibody specifically detects MSI2 in WB, ELISA and IHC. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for MSI2 antibody (ABIN969295)

Target: MSI2 (Musashi Homolog 2 (MSI2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MSI2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 2C11

Product Details anti-MSI2 Antibody

Purpose: MSI2 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human MSI2 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-MSI2 antibody (ABIN969295)

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

De Weer, Speleman, Cauwelier, Van Roy, Yigit, Verhasselt, De Moerloose, Benoit, Noens, Selleslag, Lippert, Struski, Bastard, De Paepe, Vandenberghe, Hagemeijer, Dastugue, Poppe: "EVI1 overexpression in t(3;17) positive myeloid malignancies results from juxtaposition of EVI1 to the MSI2 locus at 17q22." in: Haematologica, Vol. 93, Issue 12, pp. 1903-7, (2008) (PubMed).

Target Details for MSI2

Target: MSI2 (Musashi Homolog 2 (MSI2))

Alternative Name: MSI2

Background: Msi2 (musashi homolog 2), also known as MSI2H, is a 328 amino acid protein that localizes to the cytoplasm and contains two RRM (RNA recognition motif) domains. Expressed ubiquitously at low levels, Msi2 functions as an RNA binding protein that, by regulating the expression of target mRNAs, is thought to play a role in the proliferation and maintenance of stem cells within the central nervous system. Msi2 is subject to posttranslational phosphorylation and is upregulated in response to brain injury, suggesting a role in healing and brain tissue regeneration. Chromosomal aberrations involving the Msi2 gene are associated with the progression of chronic myeloid leukemia. Multiple isoforms of Msi2 exist due to alternative splicing events.Tissue specificity: Ubiquitous, detected at low levels.

Molecular Weight: 35 kDa

UniProt: Q96DH6