NKX3-1 antibody

Catalog No. ABIN969316

This Mouse Monoclonal antibody specifically detects NKX3-1 in WB, IHC, ELISA and FACS. It exhibits reactivity toward Human and has been mentioned in 4+ publications.

Quick Overview for NKX3-1 antibody (ABIN969316)

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NKX3-1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 4H4

Product Details anti-NKX3-1 Antibody

Purpose: NKX3A Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human NKX3A expressed in E. Coli.

Isotype: IgG2b

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-NKX3-1 antibody (ABIN969316)

Zhang, Liu, Zhang, Guan, Chen, Cui, Liu, Jiang: "Gene expression profiles in the PC-3 human prostate cancer cells induced by NKX3.1." in: Molecular biology reports, Vol. 37, Issue 3, pp. 1505-12, (2010) (PubMed).

Lee, Jadhav, Ayer, Rojas, Hyong, Lekic, Stier, Martin, Zhang: "The antioxidant effects of melatonin in surgical brain injury in rats." in: Acta neurochirurgica. Supplement, Vol. 102, pp. 367-71, (2009) (PubMed).

Zhang, Fillmore, Zimmer: "Structural and functional analysis of domains mediating interaction between the bagpipe homologue, Nkx3.1 and serum response factor." in: Experimental biology and medicine (Maywood, N.J.), Vol. 233, Issue 3, pp. 297-309, (2008) (PubMed).

Jiang, Yu, Zhang, Chen, Liu, Hu, Zhang: "p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line." in: Experimental & molecular medicine, Vol. 38, Issue 6, pp. 625-33, (2007) (PubMed).

Target Details for NKX3-1

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Alternative Name: NKX3A

Background: Nkx3.1 is a transcription factor that may play an important role in regulating proliferation of glandular epithelium and in the formation of ducts in the prostate. It has been thought to be one of the target genes of the 8p21 loss of heterozygosity, common in prostate cancer. But neither disruption of the coding region of the gene, nor mutations have been found in prostate cancer.

Molecular Weight: 26.3 kDa

Gene ID: 4824

UniProt: Q99801

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus