PGA5 antibody

Catalog No. ABIN969350

The Mouse Monoclonal anti-PGA5 antibody has been validated for WB, ELISA and IHC. It is suitable to detect PGA5 in samples from Human.

Quick Overview for PGA5 antibody (ABIN969350)

Target: PGA5 (Pepsinogen 5, Group I (Pepsinogen A) (PGA5))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PGA5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Clone: 2C1

Product Details anti-PGA5 Antibody

Purpose: PGA5 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human PGA5 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Target Details for PGA5

Target: PGA5 (Pepsinogen 5, Group I (Pepsinogen A) (PGA5))

Alternative Name: PGA5

Background: PGA5: Pepsinogen 5, group I (pepsinogen A). Pepsinogens are the inactive precursors of pepsin, the major acid protease found in the stomach. Pepsin is one of the main proteolytic enzymes secreted by the gastric mucosa. Pepsin consists of a single polypeptide chain and arises from its precursor, pepsinogen, by removal of a 41 amino acid segment from the N-terminus. Pepsinogen is synthesized in the stomach lining, and hydrochloric acid, also produced by the gastric mucosa, is necessary to convert the inactive enzyme and to maintain the optimum acidity ( pH 1-3) for pepsin function. Pepsin is particularly effective in cleaving peptide bonds involving aromatic amino acids. Pepsin shows extremely broad specificity, although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent. PGA5 is a member of the subfamily A1 within the pepsin family and is the predominant endopeptidase in the gastric juice of vertebrates. PGA5 is inhibited by ovUS-1, a uterine serpin.

Molecular Weight: 42 kDa

Gene ID: 5222

UniProt: P0DJD9