PROZ antibody

Catalog No. ABIN969368

The Mouse Monoclonal anti-PROZ antibody has been validated for WB and ELISA. It is suitable to detect PROZ in samples from Human. There are 2+ publications available.

Quick Overview for PROZ antibody (ABIN969368)

Target: PROZ (Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PROZ antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 2B4

Product Details anti-PROZ Antibody

Purpose: PROZ Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of PROZ expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-PROZ antibody (ABIN969368)

Blyth, Favaloro, Harris, Kairaitis: "Protein Z is reduced in chronic kidney disease and not elevated in patients on haemodialysis." in: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis, Vol. 19, Issue 1, pp. 23-5, (2008) (PubMed).

Paidas, Ku, Lee, Manish, Thurston, Lockwood, Arkel: "Protein Z, protein S levels are lower in patients with thrombophilia and subsequent pregnancy complications." in: Journal of thrombosis and haemostasis : JTH, Vol. 3, Issue 3, pp. 497-501, (2005) (PubMed).

Target Details for PROZ

Target: PROZ (Protein Z, Vitamin K-Dependent Plasma Glycoprotein (PROZ))

Alternative Name: PROZ

Background: PROZ protein Z, vitamin K-dependent plasma glycoprotein. It is 62 kDa large and 396 amino acids long. It has four domains: a gla-rich region, two EGF-like domains and a trypsin-like domain. It lacks the serine residue that would make it catalytically active as a serine protease. It is a member of the coagulation cascade, the group of blood proteins that leads to the formation of blood clots. It is vitamin K-dependent, and its functionality is therefore impaired in warfarin therapy. It is a glycoprotein. Although it is not enzymatically active, it is structurally related to several serine proteases of the coagulation cascade: factors VII, IX, X and protein C. The carboxyglutamate residues (which require vitamin K) bind protein Z to phospholipid surfaces. The main role of protein Z appears to be the degradation of factor Xa. This is done by protein Z-related protease inhibitor (ZPI), but the reaction is accelerated 1000-fold by the presence of protein Z. Oddly, ZPI also degrades factor XI, but this reaction does not require the presence of protein Z. In some studies, deficiency states have been associated with a propensity to thrombosis. Others, however, link it to bleeding tendency, there is no clear explanation for this, as it acts physiologically as an inhibitor, and deficiency would logically have led to a predisposition for thrombosis.

Molecular Weight: 45 kDa

Gene ID: 8858

UniProt: P22891