Reticulon 3 antibody

Catalog No. ABIN969388

This Mouse Monoclonal antibody specifically detects Reticulon 3 in ELISA and ICC. It exhibits reactivity toward Human and has been mentioned in 4+ publications.

Quick Overview for Reticulon 3 antibody (ABIN969388)

Target: Reticulon 3 (RTN3)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Reticulon 3 antibody is un-conjugated

Application: ELISA, Immunocytochemistry (ICC)

Clone: 1E11

Product Details anti-Reticulon 3 Antibody

Purpose: RTN3 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of RTN3 expressed in E. Coli.

Isotype: IgG2a

Application Details

Application Notes:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Reticulon 3 antibody (ABIN969388)

Kim, Chai, Ryu: "Selenoprotein W as molecular target of methylmercury in human neuronal cells is down-regulated by GSH depletion." in: Biochemical and biophysical research communications, Vol. 330, Issue 4, pp. 1095-102, (2005) (PubMed).

Cai, Saiyin, Lin, Zhang, Tang, Pan, Yu: "Identification of a new RTN3 transcript, RTN3-A1, and its distribution in adult mouse brain." in: Brain research. Molecular brain research, Vol. 138, Issue 2, pp. 236-43, (2005) (PubMed).

Wakana, Koyama, Nakajima, Hatsuzawa, Nagahama, Tani, Hauri, Melançon, Tagaya: "Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi." in: Biochemical and biophysical research communications, Vol. 334, Issue 4, pp. 1198-205, (2005) (PubMed).

Oertle, Klinger, Stuermer, Schwab: "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 17, Issue 10, pp. 1238-47, (2003) (PubMed).

Target Details for Reticulon 3

Target: Reticulon 3 (RTN3)

Alternative Name: RTN3

Background: RTN3, reticulon 3. The reticulons are a group of highly conserved genes with preferential expression in neuroendocrine tissues. RTN3 may be involved in membrane trafficking in the early secretory pathway. Inhibits BACE1 activity and amyloid precursor protein processing. May induce caspase-8 cascade and apoptosis. May favor BCL2 translocation to the mitochondria upon endoplasmic reticulum stress. In case of enteroviruses infection, RTN3 may be involved in the viral replication or pathogenesis. There are 5 isoforms.

Molecular Weight: 113 kDa

UniProt: O95197