LKB1 antibody

Catalog No. ABIN969424

This Mouse Monoclonal antibody specifically detects LKB1 in WB, ELISA and FACS. It exhibits reactivity toward Human, Mouse and Monkey and has been mentioned in 3+ publications.

Quick Overview for LKB1 antibody (ABIN969424)

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reactivity: Human, Mouse, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This LKB1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Clone: 4H12

Product Details anti-LKB1 Antibody

Purpose: STK11 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human STK11 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-LKB1 antibody (ABIN969424)

Al-Nashash, Fatoo, Mirza, Ahmed, Agrawal, Thakor, All: "Spinal cord injury detection and monitoring using spectral coherence." in: IEEE transactions on bio-medical engineering, Vol. 56, Issue 8, pp. 1971-9, (2009) (PubMed).

Shaw: "Tumor suppression by LKB1: SIK-ness prevents metastasis." in: Science signaling, Vol. 2, Issue 86, pp. pe55, (2009) (PubMed).

Cheng, Liu, Wang, Zou, Santiago, Garbitt, Gjoerup, Iglehart, Miron, Richardson, Hahn, Zhao: "SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis." in: Science signaling, Vol. 2, Issue 80, pp. ra35, (2009) (PubMed).

Target Details for LKB1

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Alternative Name: STK11

Background: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver.

Molecular Weight: 54 kDa

Gene ID: 6794

UniProt: Q15831

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effect