TNNI2 antibody

Catalog No. ABIN969441

This anti-TNNI2 antibody is a Mouse Monoclonal antibody detecting TNNI2 in IHC, ELISA and FACS. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for TNNI2 antibody (ABIN969441)

Target: TNNI2 (Fast Skeletal Troponin I (TNNI2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TNNI2 antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 2F12A11

Product Details anti-TNNI2 Antibody

Purpose: TNNI2 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human TNNI2 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-TNNI2 antibody (ABIN969441)

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Moran, Garriock, Miller, Heimark, Gregorio, Krieg: "Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle." in: Cell motility and the cytoskeleton, Vol. 65, Issue 8, pp. 652-61, (2008) (PubMed).

Target Details for TNNI2

Target: TNNI2 (Fast Skeletal Troponin I (TNNI2))

Alternative Name: TNNI2

Background: This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.

Molecular Weight: 21 kDa

Gene ID: 7136

UniProt: P48788