VCAM1 antibody

Catalog No. ABIN969452

Product Details anti-VCAM1 Antibody

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This VCAM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Purpose: VCAM1 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human VCAM1 expressed in E. Coli.

Clone: 6G9

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-VCAM1 antibody (ABIN969452)

Luo, Fang, Hsieh, Chi, Lin, Hsiao, Wu, Wang, Yang: "Involvement of MAPKs and NF-kappaB in tumor necrosis factor alpha-induced vascular cell adhesion molecule 1 expression in human rheumatoid arthritis synovial fibroblasts." in: Arthritis and rheumatism, Vol. 62, Issue 1, pp. 105-16, (2010) (PubMed).

Rubio-Guerra, Vargas-Robles, Serrano, Lozano-Nuevo, Escalante-Acosta: "Correlation between the levels of circulating adhesion molecules and atherosclerosis in type-2 diabetic normotensive patients: circulating adhesion molecules and atherosclerosis." in: Cell adhesion & migration, Vol. 3, Issue 4, pp. 369-72, (2009) (PubMed).

Target Details for VCAM1

Target: VCAM1 (Vascular Cell Adhesion Molecule 1 (VCAM1))

Alternative Name: VCAM1 (VCAM1 Products)

Background: This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Two alternatively spliced transcripts encoding different isoforms have been described for this gene.Tissue specificity: Expressed on inflamed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue.INVITROGEN: CD106 is expressed on bone marrow stromal cells, myeloid cells, and endothelial cells.

Molecular Weight: 81 kDa

Gene ID: 7412

UniProt: P19320

Pathways: Carbohydrate Homeostasis