NK2 Homeobox 5 antibody

Catalog No. ABIN969487

This Mouse Monoclonal antibody specifically detects NK2 Homeobox 5 in ELISA. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for NK2 Homeobox 5 antibody (ABIN969487)

Target: NK2 Homeobox 5 (NKX2-5)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NK2 Homeobox 5 antibody is un-conjugated

Application: ELISA

Clone: 2E1

Product Details anti-NK2 Homeobox 5 Antibody

Purpose: NKX2.5 Antibody

Purification: Ascitic fluid

Immunogen: Purified recombinant fragment of human NKX2.5 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1/10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-NK2 Homeobox 5 antibody (ABIN969487)

Brewer, Alexandrovich, Mjaatvedt, Shah, Patient, Pizzey: "GATA factors lie upstream of Nkx 2.5 in the transcriptional regulatory cascade that effects cardiogenesis." in: Stem cells and development, Vol. 14, Issue 4, pp. 425-39, (2005) (PubMed).

Ikeda, Hiroi, Hosoda, Utsunomiya, Matsuo, Ito, Inoue, Sumiyoshi, Takano, Nagai, Komuro: "Novel point mutation in the cardiac transcription factor CSX/NKX2.5 associated with congenital heart disease." in: Circulation journal : official journal of the Japanese Circulation Society, Vol. 66, Issue 6, pp. 561-3, (2002) (PubMed).

Target Details for NK2 Homeobox 5

Target: NK2 Homeobox 5 (NKX2-5)

Alternative Name: NKX2.5

Background: NKX2.5: NK2 transcription factor related, locus 5 (Drosophila), also known as CSX. It is a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. Mutations in this gene cause atrial septal defect with atrioventricular conduction defect, and also tetralogy of Fallot, which are both heart malformation diseases. Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition. Alternative splicing results in multiple transcript variants.

Molecular Weight: 35 kDa

Gene ID: 1482

UniProt: P52952

Pathways: Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development