HSP90AA1 antibody

Catalog No. ABIN969528

This anti-HSP90AA1 antibody is a Mouse Monoclonal antibody detecting HSP90AA1 in WB, IHC, ELISA and FACS. Suitable for Human, Mouse and Monkey. This Primary Antibody has been cited in 2+ publications.

Quick Overview for HSP90AA1 antibody (ABIN969528)

Target: HSP90AA1 (Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 1 (HSP90AA1))

Reactivity: Human, Mouse, Monkey

Host: Mouse

Clonality: Monoclonal

Conjugate: This HSP90AA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Clone: 5G5

Product Details anti-HSP90AA1 Antibody

Purpose: HSP90AA1 Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human HSP90AA1 expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-HSP90AA1 antibody (ABIN969528)

Johnston, Geoffroy, Sobala, Hay, Hutvagner: "HSP90 protein stabilizes unloaded argonaute complexes and microscopic P-bodies in human cells." in: Molecular biology of the cell, Vol. 21, Issue 9, pp. 1462-9, (2010) (PubMed).

Bao, Lai, Wang, Qu, Yin, Zifcak, Tao, Wang, Atoyan, Samson, Forrester, Xu, DellaRocca, Borek, Zhai, Cai, Qian: "Targeting heat shock protein 90 with CUDC-305 overcomes erlotinib resistance in non-small cell lung cancer." in: Molecular cancer therapeutics, Vol. 8, Issue 12, pp. 3296-306, (2009) (PubMed).

Target Details for HSP90AA1

Target: HSP90AA1 (Heat Shock Protein 90kDa alpha (Cytosolic), Class A Member 1 (HSP90AA1))

Alternative Name: HSP90AA1

Background: HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (MIM 140572), a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1, MIM 191175) and mitochondria (TRAP1, MIM 606219) (Chen et al., 2005 [PubMed 16269234]).

Molecular Weight: 90 kDa

UniProt: P07900

Pathways: M Phase, Regulation of Cell Size, Signaling Events mediated by VEGFR1 and VEGFR2, VEGFR1 Specific Signals