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anti-Human Calpain S1 Antibodies:
anti-Rat (Rattus) Calpain S1 Antibodies:
anti-Mouse (Murine) Calpain S1 Antibodies:
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Human Monoclonal Calpain S1 Primary Antibody for IF, IHC (p) - ABIN560162
Barker, Leonard, Hansen, Trawick, Ingram, Burdett, Lebold, Walker, Traber: Vitamin E and C supplementation does not ameliorate muscle dysfunction after anterior cruciate ligament surgery. in Free radical biology & medicine 2009
Show all 3 Pubmed References
Cow (Bovine) Polyclonal Calpain S1 Primary Antibody for WB - ABIN2787678
Kulkarni, Liu, Qi, Zhu, Klinke, Liu: Differential proteomic analysis of caveolin-1 KO cells reveals Sh2b3 and Clec12b as novel interaction partners of caveolin-1 and Capns1 as a potential mediator of caveolin-1-induced apoptosis. in The Analyst 2013
Human Polyclonal Calpain S1 Primary Antibody for IHC, WB - ABIN6677553
Liu, Lou, Li, Xu, Ruan, Xiao, Qiu, Bao, Yuan, Huang, Wang, Cao, Chen, Yang, Zhang: Calpain and AR-V7: Two potential therapeutic targets to overcome acquired docetaxel resistance in castration-resistant prostate cancer cells. in Oncology reports 2018
Human Polyclonal Calpain S1 Primary Antibody for ICC, IF - ABIN4287346
Wang, Palme, Rotter, Schilcher, Cukaj, Wang, Ladurner, Heiss, Stangl, Dirsch, Atanasov: Piperine inhibits ABCA1 degradation and promotes cholesterol efflux from THP-1-derived macrophages. in Molecular nutrition & food research 2016
Collectively, these data suggested the tumor suppressive role of miR-337-3p in ccRCC. MiR-337-3p suppressed cell proliferation and metastasis in lear cell renal cell carcinoma partially via targeting Capn4.
Suppression of Capn4 by miR-520b inhibits the growth and invasion of prostate cancer cells associated with downregulated Wnt/beta-catenin signaling.
Low calpain 4 expression is associated with ovarian cancer.
that Capn4 promotes cell proliferation by increasing MAPK7 expression
Calpain small subunit 1 (Capn4) overexpression increased the protein level of cleaved talin and and activated the focal adhesion kinase (FAK)/AKT/MAPK signaling in 786-O cells, while Capn4 silencing decreased the protein level of cleaved talin in Caki-1 cells.
Capn4 and miR-1271 may serve as potential therapeutic targets for the treatment of colorectal cancer.
MALAT1 and Capn4 were up-regulated while miR-124 expression was down-regulated in nasopharyngeal carcinoma cell lines.
Capn4 promotes epithelial-mesenchymal transition in human melanoma cells through activation of the Wnt/beta-catenin pathway.
CAPNS1 depletion is coupled to impairment of breast cancer cell growth.
High levels of Capn4 expression were associated with lymph node metastasis and large tumor size in non-small cell lung cancer patients.Capn4 promotes non-small cell lung cancer progression via upregulation of matrix metalloproteinase 2.
HBXIP was able to up-regulate Capn4 at the levels of promoter.
The overexpression of Capn4 is a novel negative prognostic marker, and Capn4 may be used as a new target in therapeutic strategies for human glioma.
Capn4 can contribute to hepatocellular carcinoma growth and metastasis
Capn4 mRNA and protein are increased in human clear cell renal cell carcinoma tissues and higher Capn4 levels are associated with advanced clinical tumour stage and shorter overall survival.
Capn4 upregulated MMP2 via nuclear factor-kappaB activation, manifested by increased phosphorylation of p65, a subunit of NF-kappaB.
This study suggests that augmented calpain activity is associated with increased incidence of thrombosis under hypoxic environments.
Capn4 overexpression was implicated in ICC metastasis/invasion, and Capn4 overexpression may be used as a molecular therapeutic target for intrahepatic cholangiocarcinoma
The expression of both CAPN 1 and CAPNS 1 is increased in transplant kidneys with acute rejection, and increased expression of CAPN 1 alone was observed in kidneys with chronic rejection.
The authors conclude that hepatitis B virus X protein upregulate Capn4 through NF-kappaB/p65 to promote migration of hepatoma cells.
CAPNS1 depletion is coupled to reduced levels of H2AX phosphorylation, not only in Ras(v12) induced BJ-ET fibroblasts, but also in a number of cellular systems upon genotoxic stress
Mitochondrial calpain-1 disrupts ATP synthase, leading to mitochondrial reactive oxygen species generation, which promotes proinflammatory response and myocardial dysfunction during endotoxemia.
Calpain in osteoblasts regulates cell proliferation through its regulation of p27Kip1. Osteoblast-specific capns1 knockout mice developed a high-fat diet-induced excess body weight gain and impaired glucose tolerance.
effects of Capn4 deletion may be mediated through prevention of IkappaB degradation and NF-kappaB activation, resulting in inhibition of inflammatory responses.
Calpain 4 is essential for the tyrosine phosphorylation of galectin-3, and its ultimate secretion from the cell, and its secretion probably interferes with the production of traction forces.
osteoblast-specific Capns1 knockout mice with osteoporosis and reduced bone resorptive function, exhibited reduced serum uncarboxylated osteocalcin levels and a lean phenotype under a normal chow diet.
Calpain 4 is not necessary for LFA-1-mediated adhesion, conjugation or migration.
Data suggest that the calpain small subunit, Capn4, is essential for proper chondrocyte functions in embryonic growth plates.
calpain-mediated endoproteolytic cleavage of PrP(Sc) may be an important event in prion propagation
In calpain-deficient cells, autophagy is impaired with a resulting dramatic increase in apoptotic cell death.
The molecular ordering of PARP-1, calpains, Bax, and AIF activation is established.
results suggest a regulatory connection between calpain and RhoGDI-1 in promoting formation of membrane blebs
Capn4 in cells of the osteoblast lineage impairs cell proliferation, differentiation, and bone formation
Capn4 plays an important role in the production of mechanical forces and in mediating mechanosensing during fibroblast migration and is a regulatory subunit for calpain 1 and calpain 2
CAPNS1 interferes with PP2A-Akt interaction consequently affecting FoxO3A-dependent cell death.
Capn4 overexpression underlies invasion and metastasis after liver transplantation for hepatocellular carcinoma and may be a candidate biomarker for future diagnosis and a target for therapy.
A new single nucleotide polymorphism was found in the bovine CAPNS1 gene exon 11 coding for the 3'UTR.
Polymorphisms in PPARGC1A and CAPNS1 genes may affect meat quality traits.
Calpains are a ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. Calpain families have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. Calpain I and II are heterodimeric with distinct large subunits associated with common small subunits, all of which are encoded by different genes. This gene encodes a small subunit common to both calpain I and II and is associated with myotonic dystrophy. Two transcript variants encoding the same protein have been identified for this gene.
CANP small subunit
, calcium-activated neutral proteinase small subunit
, calcium-dependent protease small subunit 1
, calcium-dependent protease, small subunit
, calpain 4, small subunit (30K)
, calpain regulatory subunit
, calpain small subunit 1
, calpain, small polypeptide
, calpain 4
, calpain, small subunit 1
, calpain I light subunit
, calpain II small subunit