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anti-Human Caspase 1 Antibodies:
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Human Monoclonal Caspase 1 Primary Antibody for IHC, IHC (p) - ABIN252521
Dorfleutner, Bryan, Talbott, Funya, Rellick, Reed, Shi, Rojanasakul, Flynn, Stehlik: Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation. in Infection and immunity 2007
Show all 26 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for IHC (p), WB - ABIN3043221
Xu, Liu, Zhang, Wang, Wang, Yang, Huo, Sun: Apoptosis-related protein expression in rabbits with blast brain injury following early hyperbaric oxygen therapy. in Neural regeneration research 2015
Show all 21 Pubmed References
Mouse (Murine) Polyclonal Caspase 1 Primary Antibody for WB - ABIN5518669
Huang, Huang, Xiao, Yang, Lin, Diao: Kallistatin, a novel anti-angiogenesis agent, inhibits angiogenesis via inhibition of the NF-?B signaling pathway. in Biomedicine & pharmacotherapy = Biome?decine & pharmacothe?rapie 2014
Show all 21 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for IHC (p), WB - ABIN3044293
Mao, Song, Li, Lv, Zhao, Li, Feng, Chen: 8-hydroxy-2-(di-n-propylamino)tetralin intervenes with neural cell apoptosis following diffuse axonal injury. in Neural regeneration research 2014
Show all 21 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for ICC, IF - ABIN4288002
Draganov, Gopalakrishna-Pillai, Chen, Zuckerman, Moeller, Wang, Ann, Lee: Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. in Scientific reports 2015
Show all 5 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for IF, IP - ABIN222877
Peluffo, Bussmann, Stouffer, Tesone: Expression of caspase-2, -3, -8 and -9 proteins and enzyme activity in the corpus luteum of the rat at different stages during the natural estrous cycle. in Reproduction (Cambridge, England) 2006
Show all 5 Pubmed References
Human Monoclonal Caspase 1 Primary Antibody for IHC (p), ELISA - ABIN560170
Choi, Stottmann, Yang, Meyers, Klingensmith: The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. in Circulation research 2007
Show all 2 Pubmed References
Human Polyclonal Caspase 1 Primary Antibody for IHC, IHC (p) - ABIN4287999
Dumas, Amiable, de Rivero Vaccari, Chae, Keane, Lacroix, Vallières: The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis. in PLoS pathogens 2014
Human Polyclonal Caspase 1 Primary Antibody for ICC, IF - ABIN4288006
Kariya, Okano, Zhao, Kataoka, Yoshinobu, Maeda, Ishihara, Higaki, Nishizaki: Activation of NLRP3 inflammasome in human middle ear cholesteatoma and chronic otitis media. in Acta oto-laryngologica 2016
The increased expression of NLRP3 (show NLRP3 Antibodies) and caspase-1 in fetal membrane and placental tissues may be associated with the development of premature rupture of membrane.
inflammasome activation and pyroptosis in human microglia and ODCs in vitro after exposure to inflammatory stimuli and demonstrate caspase-1 inhibition by the small-molecule inhibitor VX-765 in both cell types. GSDMD (show GSDMD Antibodies) inhibition by siRNA transduction suppressed pyroptosis in human microglia.
Increased production of caspase-1 in the gut (show GUSB Antibodies)-associated lymphoid tissue and peripheral blood of HIV infected patients.
Low CASP1 expression is associated with prostate cancer.
These findings confirm the involvement of caspase-1 in non-classical secretion mechanisms and open novel perspectives for the extracellular function of secreted GBP-1 (show GBP1 Antibodies).
this study demonstrates that the G+7/in6A and A10370-G polymorphisms of the CASP1 gene are associated with increased risk of developing acute coronary syndrome in Mexican population
After genotype calling and quality control filtering with exclusion of 3 cases and 3 controls, association analysis was performed across 76 directly genotyped SNPs in NLRP1 (show NLRP1 Antibodies), CARD, and CASP1 genes, adjusting for age, sex, and population stratification
Caspase-1 role in pyroptosis in glioma cells.Mir-214 regulates caspase-1 expression in glioma.
Data show that cyclic stretch activated the nucleotide-binding oligomerization domain-like receptor containing pyrin (show MEFV Antibodies) domain 1 and 3 (NLRP1 (show NLRP1 Antibodies) and NLRP3 (show NLRP3 Antibodies)) inflammasomes and induced the release of IL-1beta (show IL1B Antibodies) and pyroptosis via a caspase-1-related mechanism in human periodontal ligament cells (HPDLCs).
Caspase-1 directly cleaves alpha-Synuclein, generating a highly aggregation-prone species in neurons.
Casp1Null mice expressed caspase-11 (show CASP4 Antibodies) proteins and did not secrete IL-1beta (show IL1B Antibodies) and IL-18 (show IL18 Antibodies) or undergo pyroptosis in response to canonical NLRP3 (show NLRP3 Antibodies), NLRC4 (show NLRC4 Antibodies) or AIM2 (show AIM2 Antibodies) inflammasome activators.
The enzymatic activities of caspase-1 and caspase-11 (show CASP4 Antibodies) are required for growth inhibition in different cell types.These results reveal that these proteases have important functions beyond the direct induction of pyroptosis and proinflammatory cytokine secretion in the control of growth and elimination of cytosolic bacteria.
Collectively, these results are consistent with a model whereby the type III secretion system apparatus of Pseudomonas aeruginosa activates the caspase-1-dependent inflammasome and caspase-3 (show CASP3 Antibodies)/7 through an ASC (show STS Antibodies)-dependent mechanism.
The results of this study indicated that beta-Amyloid peptide (show APP Antibodies)-induced caspase-1 activation, disrupts autophagy in the cortex and in the hippocampus resulting in neurodegeneration and memory loss.
caspase-1 regulates dopaminergic neuronal death in the pathogenesis of Parkinson's disease in mice via caspase-7 (show CASP7 Antibodies)/PARP1 (show PARP1 Antibodies)/AIF (show AIFM1 Antibodies) pathway.
RIP3 (show MPRIP Antibodies)-mediated activation of caspase-1 rather than necroptosis-dependent inflammation was responsible for aggressive inflammation in influenza A (H7N9) virus-infected mice.
we assessed the role of RIP3 (show MPRIP Antibodies) in synergy with Caspase-1 in the induction of IL-1beta (show IL1B Antibodies) production in BMDM after either LPS (show TLR4 Antibodies)/ATP or Chlamydia muridarum stimulation. The possibility of pyroptosis and necroptosis interplays and the role of RIP3 (show MPRIP Antibodies) in IL-1beta (show IL1B Antibodies) production during Chlamydia muridarum infection in BMDM was investigated as well.
Studied the role of transient receptor potential melastatin 2 (show TRPM3 Antibodies) (TRPM2 (show TRPM2 Antibodies)) in activating caspase-1 and caspase-1-dependent pyroptosis in mouse BMDMs. Found TRPM2 (show TRPM2 Antibodies) knockout caused higher caspase-1 activation and pyrotopsis.
The results demonstrate the activation of the caspase 1 precursor by caspase 11 (show CASP4 Antibodies) and suggest a new mechanism of protection of Theiler murine encephalomyelitis virus-infected astrocytes from apoptosis.
Nodakenin inhibited the mRNA expression and production of pro-inflammatory cytokines and caspase-1 activation
Src kinase (show CSK Antibodies) mediates hypoxia-induced caspase-1 activation in the cerebral cortex of newborn piglets
endometrial expression of CASP1 and IL18 (show IL18 Antibodies) associated with pregnancy establishment; alteration of CASP1 and IL18 (show IL18 Antibodies) following premature exposure of uterus to estrogen during early pregnancy may contribute to conceptus loss between Days 15 to 18 of pregnancy
drICE (show CASP3 Antibodies) and dcp-1 (show ACE Antibodies) function in cell death redundantly. However, dying neurons in a few clusters strictly required drICE (show CASP3 Antibodies) but not dcp-1 (show ACE Antibodies), but required drICE (show CASP3 Antibodies) and dcp-1 (show ACE Antibodies) when drICE (show CASP3 Antibodies) activity was reduced via hypomorphic mutation.
Drosophila corazonin-producing interneuron programmed cell death utilizes dronc, strica, dcp-1 (show ACE Antibodies), and ice
Autophagy suppresses Dcp-1 (show ACE Antibodies)-mediated apoptotic cell death, whereas Dcp-1 (show ACE Antibodies) positively regulates autophagy, possibly through feedback regulation.
novel characteristic morphological features of egg chambers lacking both dcp-1 (show ACE Antibodies) and pita functions in the germline cells; suggested an essential role of dcp-1 (show ACE Antibodies) and/or pita during mid-oogenesis
A double-mutant analysis between drICE (show CASP3 Antibodies) and death caspase-1 (dcp-1), another effector caspase (show CASP3 Antibodies), reveals that some cells (type I) strictly require drICE (show CASP3 Antibodies) for apoptosis, whereas other cells (type II) require either drICE (show CASP3 Antibodies) or dcp-1 (show ACE Antibodies).
Data show that the effector caspase Dcp-1 and the inhibitor of apoptosis protein (show BIRC2 Antibodies) Bruce (show BIRC6 Antibodies) function to regulate both autophagy and starvation-induced cell death in Drosophila.
HeT-A mRNA is derepressed in mRNA degradation mutants dcp1 (show ACE Antibodies), indicating that the enzyme also aid in removing full-length transcripts and/or decay intermediates.
Bombyx mori caspase-1 plays an important role during baculovirus infection.
cBm-IAP1 (show BIRC3 Antibodies) is a vital negative regulator of apoptosis in BM-N cells and functions by preventing the activation and/or activity of Bm-Dronc and Bm-caspase-1.
Activation of Atg5 (show ATG5 Antibodies), AIF (show AIFM1 Antibodies) and caspase (show CASP3 Antibodies) genes in close association with different cell death events revealed the synchronized differential expression of apoptosis-associated genes in response to macroparasitism.
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
CASP1 nirs variant 1
, IL-1 beta-converting enzyme
, caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
, interleukin 1, beta, convertase
, interleukin 1-B converting enzyme
, IL-1B converting enzyme
, interleukin 1 beta-converting enzyme
, interleukin-1 beta convertase
, interleukin-1 beta-converting enzyme
, Interleukin 1beta converting enzyme
, caspase 1, apoptosis-related cysteine protease (interleukin 1, beta, convertase)
, interleukin-1 beta converting enzyme
, caspase-1/caspase-4 hybrid
, caspase 1
, death caspase-1