Browse our anti-CD11b (ITGAM) Antibodies

Mouse (Murine) Integrin alpha M (ITGAM) interaction partners

1. Neutrophil CD11b/CD18 limits pathology in influenza-induced, T cell-mediated disease.

2. The authors demonstrate a new, surprising atheroprotective role of alphaMbeta2 in female ApoE(-/-) mice. alphaMbeta2 maintains estrogen receptor expression in macrophages and 17beta-estradiol E2-dependent inhibition of foam cell formation.

3. CD11b activation promotes pro-inflammatory macrophage polarization by stimulating expression of microRNA Let7a.

4. we demonstrated that activation of CD11b in response to TDM acts as a critical negative regulator of Mincle signaling by promoting formation of a Lyn-SIRPalpha-SHP1 complex that dephosphorylates Syk.

5. LFA-1 dominates polymorphonuclear leukocyte (PMN) adhesion on ICAM-1 and ICAM-2, while Mac-1 mediates PMN adhesion on RAGE, JAM-A, and JAM-C

6. anti-inflammatory role in experimental epidermolysis bullosa acquisita; CD11b-deficient mice expressed increased levels of circulating IFN-gamma and IL-4

7. leukocyte Mac-1 and platelet GPIbalpha are involved in thrombosis

8. results suggest that Mac-1 deficiency has little impact on the healing of small excisional and incisional wounds; moreover, the findings demonstrate that the effect of single genetic deficiencies on wound healing may markedly differ among wound models

9. These results indicated that integrin CD11b mediates alpha-synuclein-induced NOX2 activation through a RhoA-dependent pathway.

10. CD11b promotes the differentiation of osteoclasts induced by RANKL through the Syk signaling pathway.

11. These results showed that CR3 regulated Nox2 activation and dopaminergic neurodegeneration through a Src-Erk-dependent pathway in a two pesticide-induced Parkinson's disease (PD) model, providing novel insights into the immune pathogenesis of PD.

12. Adhesive properties of the leukocyte integrin Mac-1 are not required for macrophage accumulation in adipose tissue. Instead, Mac-1 modulates inflammatory gene expression in macrophages.

13. Bone marrow mesenchymal stromal cells induce the rapid differentiation of CD11b+ myeloid cells from bone marrow progenitors, and such an activity requires the expression of nitric oxide synthase-2.

14. Mac-1(-/-) pups have reduced numbers of type I alveolar cells, respiratory failure and low survival.

15. data provide evidence that the NLRC4 inflammasome contributes to resistance through regulation of caspase-1, IL-1beta and IL-18 in a CD11blowLy6Glow population of cells

16. CD11b+Gr-1+ myeloid-derived suppressor cells suppress T cells in an IFN-gamma- and nitric oxide-dependent manner to reduce atherosclerotic lesion development in LDLr deficient mice.

17. Mesenteric lymph node CD11b(-) CD103(+) PD-L1(High) dendritic cell subset probably takes up luminal antigens in the intestine, migrates to MLNs, and highly induces regulatory T cells through TGF-beta activation.

18. TLR-stimulated macrophages from CD11B SNP carriers showed increased basal expression of IFN regulatory factor 7 (IRF7) and IFN-beta, as well as increased nuclear exclusion of FOXO3, which was suppressed by LA1-dependent activation of CD11b.

19. The single nucleotide polymorphism rs1143678 substitutes Pro(1146) for Ser in the integrin alphaM cytoplasmic tail generates a noncanonical 14-3-3zeta binding site that modulates integrin alphaM(PS)beta2 outside-in signaling

20. a novel role for CR3 and microglia in brain Abeta metabolism and defining a potential new therapeutic target in Alzheimer disease.

Human Integrin alpha M (ITGAM) interaction partners

1. HES treatment impaired the chemotaxis only towards fMLP, event mainly ascribed to the inhibition of CD-11b (Mac-1 integrin) activity. Therefore, the observed effect mediated by HES should be taken into account during volume replacement therapies.

2. Complement receptor 3 (Integrin alpha-M beta-2)-mediated phagocytosis of Francisella due to increased ras GTPase-activating protein (RasGAP) activity.

3. neutrophil CD64, CD11b and Lipocalin-2 are early, specific and sensitive diagnostic markers of neonatal sepsis

4. Mast cells may convey immunoregulatory signals through C3, C3b, and iC3b to CD11b(+) cells, especially in BCC.

5. Integrin alphaM is a specific marker of activated tissue eosinophils in Eosinophilic esophagitis, and promotes eosinophil survival through interactions with periostin.

6. results identify PF4 as a ligand for the integrin Mac-1 and suggest that many immune-modulating effects previously ascribed to PF4 are mediated through its interaction with Mac-1

7. Single nucleotide polymorphisms in ITGAM, TNFSF4, TNFAIP3 and STAT4 genes are associated with susceptibility to systemic lupus erythematosus in a North Indian population.

8. Cis interaction between sialylated FcgammaRIIA and the alphaI-domain of Mac-1 alters the threshold for IgG-mediated neutrophil recruitment. A disruption of this interaction may increase neutrophil influx in autoimmune diseases.

9. A significant reduction of CD11b expression on monocytes and granulocytes, as a sign of reduced cellular inflammation, was achieved by treatment of atrial fibrillation using pulmonary vein isolation.

10. Expression of Mac-1 on the surface of human embryonic kidney (HEK) 293 cells induced their adhesion and migration to PTN. Accordingly, PTN promoted Mac-1-dependent cell spreading and initiated intracellular signaling manifested in phosphorylation of Erk1/2.

11. CD11b rs1143679 polymorphism appears to be associated with risk for SLE in the Han Chinese population, and may play an important role in the development of lupus nephritis.

12. alphaMbeta2 uses its alphaI domain to bind iC3b at the thioester domain and simultaneously interacts through a region near the alphaM beta-propeller and beta2 betaI domain with a region of the C3c moiety near the C345C domain.

13. discovered that OLFM4, CD11b, and ITGA2 are proteins that are overexpressed in both primary colon tumors and liver metastasis. These are colon cancer biomarkers with autoantigenic properties.

14. Up-regulation of granulocyte and monocyte CD11b during plasma separation was C5-dependent.

15. This study shown the ITGAM expression in Microglia and Astrocytes in stroke, Alzheimer's disease, and Lewy body dementia.

16. CD11b expression on polymorphonuclear leukocytes from patients with ankylosing spondylitis stimulated with lipopolysaccharide is not different to that of healthy controls.

17. The use of CD33(+)CD11b(+)HLA-DR(-) cells as a predictive and prognostic biomarker.

18. Bone marrow mesenchymal stromal cells induce the rapid differentiation of CD11b+ myeloid cells from bone marrow progenitors, and such an activity requires the expression of nitric oxide synthase-2.

19. demonstrate for the first time a dependency of monocyte-platelet aggregates and CD11b expression on monocytes in the presence of atrial fibrillation (AF) and support the notion of a close relationship between AF, thrombogenesis and inflammation

20. Increased CD11b+ and CD200+ monocytes in those with a strong presence of BVN indicate that BVN development may be associated with retinal injury and a VEGF-mediated process that is either reflected or propelled by systemic changes in monocytes.

Cow (Bovine) Integrin alpha M (ITGAM) interaction partners

1. These data describe the presence of specific pattern recognition receptor transcripts in the mRNA isolated from bovine neutrophil and show a CD11b-/Ca(2+) dependent ROS production

2. The molecular cloning and characterization of CD11b from cattle and its similarities to other species are presented.

Pig (Porcine) Integrin alpha M (ITGAM) interaction partners

1. molecular cloning, characterization, gene expression and chromosomal localization on region SSC3p15-17